| 醛固酮与糖尿病及其慢性并发症的关系 |
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| 引用本文： | 王霞娟,卜瑞芳,邓振霞.醛固酮与糖尿病及其慢性并发症的关系[J].医学研究生学报,2007,20(5):548-552. |
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| 作者姓名： | 王霞娟 卜瑞芳 邓振霞 |
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| 作者单位： | 南京医科大学附属无锡一院内分泌科,江苏无锡,214002 |
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| 基金项目： | 南京医科大学校科研和教改项目 |
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| 摘 要： | 醛固酮合成酶基因（CYP11B2）部分位点的多态性改变除导致血浆醛固酮水平发生改变外，还与血糖变化密切相关。作者除对醛固酮传统的水钠滞留导致容量性血压升高外，还参与或介导了血管紧张素Ⅱ的部分靶器官损伤作用，与糖尿病及其慢性并发症的发生和进展有关作一综述，并对醛固酮受体拮抗剂在糖尿病慢性并发症中的治疗意义进行了分析与讨论。
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| 关 键 词： | 醛固酮 醛固酮受体拮抗剂 糖尿病 慢性并发症 |
| 文章编号： | 1008-8199(2007)05-0548-05 |
| 修稿时间： | 2006年8月4日 |
Relationship between aldosterone and diabetes mellitus and its chronic complications |
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| WANG Xia-juan,BO Rui-fang,DENG Zhen-xia.Relationship between aldosterone and diabetes mellitus and its chronic complications[J].Bulletin of Medical Postgraduate,2007,20(5):548-552. |
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| Authors: | WANG Xia-juan BO Rui-fang DENG Zhen-xia |
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| Abstract: | Several genetic polymorphisms of the aldosterone synthase gene(CYP11B2),which may influence the plasma aldosterone levels,had been reported to influence the blood glucose levels.In addition to the effects of sodium()(and consequently water) resorption and potassium excretion(),aldosterone could be involved in the development and progression of diabetes and its chronic complications.This paper also discussed the therapeutic significance of aldosterone receptor antagonists on the occcurance of chronic diabetic complications. |
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| Keywords: | Aldosterone Aldosterone receptor antagonist Diabetes Chronic complications |
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