| 银条多糖对链脲佐菌素致糖尿病小鼠血糖的药效学观察 |
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| 引用本文： | 李向阳,齐鹏博,龚其海,吴芹,张环英,李志毅.银条多糖对链脲佐菌素致糖尿病小鼠血糖的药效学观察[J].蚌埠医学院学报,2012,37(3):254-255. |
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| 作者姓名： | 李向阳 齐鹏博 龚其海 吴芹 张环英 李志毅 |
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| 作者单位： | 商丘医学高等专科学校,药理学教研室,河南,商丘,476005;遵义医学院,药理学教研室,贵州省基础药理学重点实验室,贵州,遵义,563003;商丘市柘城县结核病防治所,河南,商丘,476200;遵义医学院,药理学教研室,贵州省基础药理学重点实验室,贵州,遵义,563003;商丘医学高等专科学校,药理学教研室,河南,商丘,476005 |
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| 摘 要： | 目的:观察银条多糖(stachys floridana schuttl.ex benth,polysaccharide,SFSBP)对链脲佐菌素致糖尿病小鼠血糖的影响。方法:将受试小鼠48只随机均分为6组,除空白对照组腹腔注射等体积生理盐水外,其余各组均腹腔注射链脲佐菌素150 mg/kg建立糖尿病小鼠模型,建模后连续给予SFSBP 10 d,采用已糖激酶法测定受试小鼠血糖水平的变化。结果:SFSBP 50、100和200 mg/kg均能明显降低链脲佐菌素所致的小鼠血糖升高(P0.01)。结论:SFSBP对链脲佐菌素所致糖尿病小鼠有降血糖作用。
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| 关 键 词： | 糖尿病 银条多糖 降糖作用 小鼠 |
Pharmacodynamics effects of stachys floridana schuttl.ex benth polysaccharide on blood sugar in streptozotocin-induced diabetic mice |
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| LI Xiang-yang
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QI Peng-bo
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GONG Qi-hai
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WU Qin
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Zhang Huan-ying
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Li Zhi-yi.Pharmacodynamics effects of stachys floridana schuttl.ex benth polysaccharide on blood sugar in streptozotocin-induced diabetic mice[J].Journal of Bengbu Medical College,2012,37(3):254-255. |
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| Authors: | LI Xiang-yang QI Peng-bo GONG Qi-hai WU Qin Zhang Huan-ying Li Zhi-yi |
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| Affiliation: | 1(1.Department of Pharmacology,Shangqiu Medical School,Shangqiu Henan 476005;2.Department of Pharmacology, Zunyi Medical College,The Key Laboratory of Basic Pharmacology of Guizhou Province,Zunyi Guizhou 563003; 3.Institute for Tuberculosis Prevention and Control,Zhecheng,Shangqiu He′nan 476200,China) |
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| Abstract: | Objective:To observe the hypoglycemic effects of stachys floridana schuttl.ex benth polysaccharide(SFSBP)in hyperglycemic mice induced by streptozotocin.Methods:Forty-eight mice were randomly divided into six groups,in addition to the blank control group,intraperitoneal injection of an equal volume of saline,the other groups were intraperitoneal injection of streptozotocin 150 mg/kg to built diabetic mice model,SFSBP was given by 10 d.The blood sugar level of mice were determined by hexose kinase method.Results:SFSBP 50,100 and 200 mg/kg could significantly decrease the blood sugar level in streptozotocin-induced diabetic mice(P<0.01).Conclusions:SFSBP has the hypoglycemic action on streptozotocin-induced diabetic mice. |
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| Keywords: | diabetes mellitus stachys floridana schuttl ex benth polysaccharide hypoglycemic effects mice |
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