硝苯啶对慢性肺心病呼衰之血液流变学与甲皱微循环的影响

本文研究了硝苯啶(Nif)对慢性肺心病急性发作期有呼吸衰竭患者的血液流变学及甲皱微循环的影响.随机分为对照组与试验组.两组均予以吸氧、抗感染及对症处理;试验组在此基础上加服Nif10mg,3次/d,连续2周,每例均在治疗前、治疗一周末及二周末分别检测全血粘度、血浆粘度、红细胞压积、血沉、血浆纤维蛋白原含量等流变学参数,并观察甲皱微循环.治疗后两组患者的全血粘度及微循环状态均有所改善,但试验组明显优于对照组,推测系由于硝苯啶能改善红细胞变形性及抑制血小板聚集能力的作用.

EFFECTS OF NIFEDIPINE ON HEMORHEOLOGY AND NAIL MICROCIRCULATION IN ACUTE EXACERBATION OF PATIENTS WITH COR PULMONALE

The effects of nifedipine on hemorheology and nail microcirculation in patients with cor pulmonale who were in acute stage with respiratory failure were studied. Twenty -two patients were assigned randomly either to trial or control group. Nifedipine was given orally in a does of l0mg three times a day for two weeks in the trial group. The routine treatment with oxygen inhalation and antibiotics were the same in both the groups. Hemorheologic parameters were measured before the study and at the end of first week,second week respectively after the begin- ning of the treatment. At the same time,nail microcirculation was observed with microcirculation microscopy. The results showed that the whole blood viscosity in the trial group lowered significantly compared with the control group (P<0. 05) after the treatment, and the condition of the nail microcirculation improved in parallel with the lowering of whole blood viscosity. The data obtained suggest that nifedipine can not only dilate the micrangium but improve the hemorheological characteristics of patients with cor pulmonale in acute exacerbation. It is supposed that nifedipine could improve deformability of red blood cells and suppress the aggregate ability of platelets.