胃肠透析液的急性毒性和对家兔肾衰模型的实验研究

为了通过动物模型验证胃肠透析液(GJD)对流行性出血热(EHF)的治疗安全度和效果,特进行如下两个方面的试验:1.急性毒性试验:对健康成年家兔和小鼠,采用临床用药量的5倍浓缩胃肠透析液,灌胃给药,连续观察一周,均未见明显毒性反应。2.对家兔急性肾衰模型的影响:用0.1％升汞引起家兔的急性肾衰模型仍用前述5倍浓缩液,按120～160ml/kg灌胃,测定透析前后的Cr和BUN值,经配对t检验并与对照组比较,证实有一定的治疗效果(P<0.01)。上述实验结果表明:胃肠透析疗法对流行性出血热的治疗是安全而有效的。

EXPERIMENTAL STUDIES OF GASTROINTESTINAL DIALYSIS SOLUTION ON THE ACUTE TOXICITY AND THE RENAL FAILURE MODEL OF THE RABBIT

In order to observe the safety and effect of gastrointeslinal dialysis ( GID ) in the treatment of epidemic bemorrhagic fever( EHF) , the following experimental studies were conducted. 1. Acute toxicity test: GID was used in adult rabbits and mice The doses given orally were five times concentrated as those used clinically. A. week's observation shows no apparent toxic reaction. 2. The test of the effect of G1D on the acute renal failure model of rabbits:The rabbits pretreated with 0.1% HgCl2 were given 120~160ml/kg of the five-fold GID. Values of Cr and BUN were determined before and after the dialysis. The test in the matched and the comparison with the controls show that GID has certain curative effects. As a conclusion, GID is considered to be safe and effective in the treatment of epidemic hemorrhagic fever.