| 复方银黄微型灌肠剂对发热大鼠下丘脑前列腺素E2含量的影响 |
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| 引用本文： | 何惠,刘华钢,庞辉,朱丹.复方银黄微型灌肠剂对发热大鼠下丘脑前列腺素E2含量的影响[J].时珍国医国药,2007,18(12):2878-2879. |
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| 作者姓名： | 何惠 刘华钢 庞辉 朱丹 |
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| 作者单位： | 1. 广西医科大学,广西,南宁,530021
2. 广西医科大学药学院,广西,南宁,530021 |
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| 基金项目： | 国家自然科学基金项目（No.30260124） |
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| 摘 要： | 目的观察复方银黄微型灌肠剂(YHCE)的解热作用及对发热大鼠下丘脑中前列腺素E2(PGE2)含量的影响,初步探索其解热机制。方法采用皮下注射20%酵母混悬液(10 ml/kg)造大鼠发热模型,1h后灌肠给药,分别于给药后2,4,6h观测肛温,用ELISA法测定大鼠下丘脑中PGE2含量。结果YHCE能在给药后2,4,6 h显著抑制大鼠体温上升(P<0.01),并在给药后2,4 h明显抑制PGE2含量的增高(P<0.05)。结论复方银黄微型灌肠剂有解热作用,而且能降低发热大鼠下丘脑的PGE2含量。
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| 关 键 词： | 复方银黄微型灌肠剂 前列腺素E2 发热 |
| 文章编号： | 1008-0805（2007）12-2878-02 |
| 收稿时间： | 2007-04-11 |
| 修稿时间： | 2007-06-12 |
Effects of Yinhuang Micro - enema on Prostaglandin E2 Content in the Febrile Rat Hypothalamus |
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| HE Hui,LIU Hua-gang,PANG Hui,ZHU Dan.Effects of Yinhuang Micro - enema on Prostaglandin E2 Content in the Febrile Rat Hypothalamus[J].Lishizhen Medicine and Materia Medica Research,2007,18(12):2878-2879. |
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| Authors: | HE Hui LIU Hua-gang PANG Hui ZHU Dan |
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| Abstract: | Objective To observe the effect of Yinhuang micro-enema(YHCE) on the content of prostaglandin E2 in the febrile rat hypothalamus and to explore the possible antipyretic mechanism of YHCE.Methods The febrile rats modle was established by injecting 20% suspension of yeast hypodermically(10 ml/kg).One hour later,the coloclysising drugs were administered respectively.Then the temperatures at 2,4 and 6h after administration were observed,the content of PGE2 was mensured by Enzyme-Linked Immunosorbnent Assay(ELISA).Results The YHCE inhibited the temperature rising at 2,4 and 6h after administration(P<0.01),and inhibited the rising of the PGE2 content at 2,4 h after administration(P<0.05).Conclusion YHCE has obvious antipyretic effect.It can decrease the PGE2 content in febrile rats hypothalamus obviously. |
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| Keywords: | Yinhuang micro-enema(YHCE) Prostaglandin E2(PGE2) Fever |
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