| 丹参对缺血再灌注引起的微循环障碍和靶器官损伤的多环节改善作用 |
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| 引用本文： | 韩晶岩,樊景禹,郭治昕,刘育英.丹参对缺血再灌注引起的微循环障碍和靶器官损伤的多环节改善作用[J].世界科学技术,2008,10(3):87-93. |
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| 作者姓名： | 韩晶岩 樊景禹 郭治昕 刘育英 |
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| 作者单位： | [1]北京大学医学部天士力微循环研究中心,北京100083 [2]北京大学基础医学院中西医结合教研室,北京100083 [3]日本庆应义塾大学医学部消化内科,日本东京160-8582 |
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| 基金项目： | 国家科技部中医药国际合作专项基金 |
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| 摘 要： | 缺血再灌注（ischemia／reperfusion，I／R）是创伤、扩血管药物治疗、溶栓治疗、介入治疗、器官移植和休克复苏治疗后再损伤的主要病理基础。I／R引起的微循环障碍是包括过氧化物产生、血管内皮细胞损伤、细胞粘附增多、血浆白蛋白漏出、肥大细胞脱颗粒、炎性因子释放等复杂的病理变化过程。对微循环障碍某一环节进行干预的传统疗法，并没有取得满意的临床疗效。
丹参作为活血中药，临床上广泛地用于心脑肝肾等脏器血瘀的治疗。近年来的基础研究结果表明丹参可以多环节地改善微循环障碍，在预防和治疗微循环障碍和靶器官损伤方面有着重要的应用前景。本文，重点介绍丹参对缺血再灌注引起的微循环障碍和靶器官损伤的多环节改善作用。
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| 关 键 词： | 丹参 缺血再灌注 器官损伤 细胞黏附 过氧化物 肥大细胞脱颗粒 |
Salvia Miltiorrhiza and Its Potentials in Ameliorating Multiple Insults in Microcirculatory Disturbance and Target Organ Injuries by Ischemia and Reperfusion |
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| Han Jingyan,Fan Jingyu Guo Zhixin Liu Yuying.Salvia Miltiorrhiza and Its Potentials in Ameliorating Multiple Insults in Microcirculatory Disturbance and Target Organ Injuries by Ischemia and Reperfusion[J].World Science and Technology(Modernization of Traditional Chinese Medicine),2008,10(3):87-93. |
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| Authors: | Han Jingyan Fan Jingyu Guo Zhixin Liu Yuying |
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| Affiliation: | Han Jingyan (Tasly Microcirculation Research Center,Beijing University Health Science Center,100083 Beijing,China,Department of Integration of Chinese , Western Medicine,Department of Internal Medicine,School of Medicine,Keio University,160-8582,Tokyo,Japan) Fan Jingyu Guo Zhixin Liu Yuying (Tasly Microcirculation Research Center,100083 Beijing) |
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| Abstract: | Ischemia and reperfusion (I/R) makes a prime pathological basis for the injuries originated from trauma,thrombol- ysis,precutaneous transluminal coronary angioplasty,organ transplantation,and hypovolemic shock with resuscitation. I/R elicits multiple insults in microcirculation,including production of peroxides,damage to vascular endothelium,en- hanced leukocyte adhesion,leakage of albumin from vessels,mast cell degranulation,and release of proinflamatory mediators.Numerous published studies have focused on... |
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| Keywords: | Salvia mihiorrhiza ischemia and reperfusion organ injury cell adhesion antioxidant mast cell degranulation |
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