通心络胶囊对慢性脑缺血患者脑血流及血液流变学的影响

目的观察通心络胶囊对慢性脑缺血患者脑血流及血液流变学的影响,并进行相应的临床疗效评定。方法慢性脑缺血患者88例,随机分为观察组45例,对照组43例。2组均按西医治疗原则,采用常规治疗方法,予控制血压、对症等治疗,同时给予尼莫地平片40 mg,每日3次口服。观察组在上述基础上予通心络胶囊4粒,每日3次口服,30日为1个疗程,连用2个疗程。采用经颅多普勒(TCD)检查分析,检测大脑中动脉(MCA)、大脑前动脉(ACA)、大脑后动脉(PCA)、椎动脉(VA)和基底动脉(BA)的平均血流速度(Vm)和搏动指数(PI)的变化情况,测定清晨空腹血液流变学指标,并进行临床疗效评定。结果观察组脑血流得到显著改善,TCD检查各项指标均优于对照组(P<0.01,P<0.05),同时显著改善血液流变学,降低异常升高的血黏度,各项指标均优于对照组(P<0.05)。临床疗效评定总有效率达100%,与对照组(79.07%)比较差异有统计学意义(P<0.01)。结论通心络胶囊对慢性脑缺血具有较好的治疗作用,能显著改善慢性脑缺血患者脑血流状况,降低异常升高的血黏度。

Effect of Tongxinluo capsule on cerebral blood flow and hemorheology in patients with chronic cerebral ischemia

Objective To observe the effect of Tongxinluo capsule on cerebral blood flow and hemorheology in patients with chronic cerebral ischemia.Methods 88 cases with chronic cerebral ischemia were randomly divided into control group(n=43) and treatment group(n=45).Patients in control group were treated by combination of routine therapy and Nimodipine(40mg,three times a day).Patients in treatment group were treated by combination of routine therapy and Tongxinluo capsule(4 pills,three times a day).The therapeutic course was 30 days in both groups.The effect was observed in two courses.Meaning blood flow rate and pulsatility index(PI) of middle cerebral artery(MCA),anterior cerebral artery(ACA),posterior cerebral artery(PCA),vertebral artery(VA) and basal artery(BA) were detected by transcranial Doppler(TCD).Results Cerebral blood flow in treatment group was obviously improved.Indexes detected by TCD in treatment group were superior to those in control group(P<0.01,P<0.05).The total effective rate in treatment group(100%) was higher than that in control group(79.07%,P<0.01).Conclusion Tongxinluo capsule has a good effect on cerebral blood flow and hemorheology in patients with chronic cerebral ischemia.