胰岛素敏感性及胰岛素样生长因子结合蛋白-1与老年痴呆症中医辨证分型关系的临床研究

目的]探讨胰岛素敏感性和血清胰岛素样生长因子结合蛋白-1(IGFBP-1)与老年痴呆症中医辨证分型的关系及临床意义。方法]将50例老年痴呆症患者分为脾肾两虚(30例)和气虚血瘀(20例)2型。对老年痴呆症组和正常对照组(30例)进行血清IGFBP-1和空腹血清胰岛素(FINS)检测,计算胰岛素敏感性指数(IAI)。结果]3组间空腹血糖(FBG)无统计学差异(P0.05);与正常对照组相比,脾肾两虚组和气虚血瘀组的FINS、IGFBP-1均偏高,有显著统计学差异(P0.01),两中医证型之间也存在统计学差异(P0.01,P0.05);脾肾两虚组和气虚血瘀组的IAI较正常对照组下降,3组间有统计学差异(P0.05);通过Pearson相关性分析可以看出,IGFBP-1与FBG、FINS、IAI有相关性,与FBG、FINS呈正相关,与IAI呈负相关。结论]老年痴呆症与胰岛素代谢水平异常有关,脾肾两虚是导致老年期痴呆的关键病机。

Relationship between insulin sensitivity,insulin-like growth factor binding protein-1 and TCM syndrome differentiation in patients with dementia

Objective] To investigate the relationship and significance between insulin sensitivity,insulin-like growth factor binding protein-1(IGFBP-1) and traditional Chinese medicine syndrome differentiation of dementia. Methods] Syndromes of 50 patients were divided into two types:asthenia of both the spleen and kidney and deficiency of vital energy and stagnation of blood. The serum fasting insulin (FINS) and IGFBP-1 of dementia group and normal group were detected. The insulin resistance index (IAI) was calcul...