| 海带对实验性高脂血症大鼠血脂水平的调节作用机制 |
| |
| 引用本文： | 徐新颖,于竹芹,帅莉,郭云良.海带对实验性高脂血症大鼠血脂水平的调节作用机制[J].中华中医药杂志,2011(2):384-387. |
| |
| 作者姓名： | 徐新颖 于竹芹 帅莉 郭云良 |
| |
| 作者单位： | 青岛大学医学院附属医院脑血管病研究所;青岛大学化学化工与环境学院; |
| |
| 基金项目： | 国家自然科学基金项目(No.40976085); 青岛大学优秀研究生学位论文培育项目资助(No.YSPY2010010)~~ |
| |
| 摘 要： | 目的:探讨海带对高脂血症大鼠血脂的调节作用机制。方法:健康雌性Wistar大鼠40只,应用高脂饲料喂养方法建立高脂血症动物模型,海带粉饲料喂养干预治疗2周。生化法检测大鼠血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及脂蛋白酯酶(LPL)和肝脂酶(HL)活性。酶联免疫吸附法测定羟甲基戊二酰辅酶A(HMG-CoA)水平和羟甲基戊二酰辅酶A还原酶(HMG-CR)活性。结果:经海带干预治疗后,动物血清TG、TC和LDL水平较模型对照组显著降低(P<0.05),而HDL水平显著升高(P<0.05)。海带治疗组动物血清和肝组织中LPL和HL水平均显著高于模型对照组(P<0.05),而显著低于阳性对照组(P<0.05)。海带治疗组动物肝组织HMG-CoA的含量显著高于模型对照组、而HMG-CR的活性显著低于模型对照组(P<0.05),且HMG-CR活性显著高于阳性对照组(P<0.05)。结论:海带可能通过增强LPL、HL和HMG-CR的活性,影响TG、TC、LDL和HDL等组分的代谢,发挥调节血脂水平的作用。
|
| 关 键 词： | 海带 高脂血症 脂蛋白酯酶 肝脂酶 羟甲基戊二酰辅酶A还原酶 大鼠 |
Regulating effects and mechanism of Laminaria japonica on serum lipid of experimental hyperlipemia rats |
| |
| XU Xin-ying,YU Zhu-qin,SHUAI Li,GUO Yun-liang.Regulating effects and mechanism of Laminaria japonica on serum lipid of experimental hyperlipemia rats[J].China Journal of Traditional Chinese Medicine and Pharmacy,2011(2):384-387. |
| |
| Authors: | XU Xin-ying YU Zhu-qin SHUAI Li GUO Yun-liang |
| |
| Affiliation: | XU Xin-ying1,YU Zhu-qin1,SHUAI Li2,GUO Yun-liang1 (1Institute of Cerebrovascular Diseases,Affiliated Hospital of Medical College,Qingdao 266003,China,2School of Chemistry,Chemical Engineering and Environmental Sciences,Qingdao University,China) |
| |
| Abstract: | Objective: To investigate the regulating effects and mechanism of Laminaria japonica on serum lipid of hyperlipemia in rats.Methods: Forty healthy female Wistar rats were used to establish hyperlipemia models by feeding fat-rich forage,and the Laminaria japonica was applied as raw materials for potential marine drugs.The levels of serum lipid including the triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL) and the activity of lipoproteinesterase(LPL) and hepati... |
| |
| Keywords: | Laminaria japonica Hyperlipemia Lipoproteinesterase Hepatic lipase HMG-CR Rats |
| 本文献已被 CNKI 等数据库收录！ |
|
