| 加味溺毒清合剂对单侧输尿管结扎大鼠肾间质纤维化的影响 |
| |
| 引用本文： | 李玉卿,陈美雪,张雪锋,丁伟伟,张忠贤,费德升,蓝小琴,陈迪.加味溺毒清合剂对单侧输尿管结扎大鼠肾间质纤维化的影响[J].上海中医药杂志,2018,52(7):96-101. |
| |
| 作者姓名： | 李玉卿 陈美雪 张雪锋 丁伟伟 张忠贤 费德升 蓝小琴 陈迪 |
| |
| 作者单位： | 浙江省平湖市中医院肾内科;浙江省平湖市精神卫生中心 |
| |
| 基金项目： | 浙江省平湖市科技计划资助项目 |
| |
| 摘 要： | 目的探讨加味溺毒清合剂治疗单侧输尿管结扎大鼠肾间质纤维化的机制。方法 SD雄性大鼠50只,除假手术组10只外,其余大鼠建立单侧输尿管结扎模型。造模后大鼠随机分为模型组、厄贝沙坦组、中药低剂量组、中药高剂量组,每组10只。分别采取相应的干预措施。检测尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG酶)、尿β_2微球蛋白(β_2-MG)、血肌酐(Scr)、血尿素氮(BUN)及肾组织中的转化生长因子β_1(TGF-β_1)和α-平滑肌肌动蛋白(α-SMA)的表达,并检查肾脏病理。结果 (1)尿β_2-MG含量:各组比较差异无统计学意义(P0.05)。(2)尿NAG酶含量:14 d、28 d时模型组、中药低剂量组、中药高剂量组与假手术组比较均增高,差异有统计学意义(P0.05);28 d时中药高剂量组与模型组比较明显减低,差异有统计学意义(P0.05)。(3)血Scr水平:15 d时中药高剂量组与模型组、厄贝沙坦组比较降低并差异有统计学意义(P0.05);29 d时,中药高剂量组与模型组比较,血Scr含量降低,差异有统计学意义(P0.05);(4)血BUN水平:中药高剂量组与厄贝沙坦组比较,血BUN含量降低,差异有统计学意义(P0.05)。29 d时,各组血BUN含量差异均无统计学意义(P0.05)。(5)肾组织α-SMA、TGF-β_1表达:与假手术组比较,厄贝沙坦组、中药低剂量组、中药高剂量组、模型组差异有统计学意义(P0.05);与模型组比较,厄贝沙坦组、中药低剂量组、中药高剂量组差异均有统计学意义(P0.05)。结论加味溺毒清合剂能够降低尿NAG酶,同时通过抑制肾组织中α-SMA及TGF-β_1表达,从而减轻肾间质纤维化的程度。
|
| 关 键 词： | 加味溺毒清合剂 单侧输尿管结扎 肾间质纤维化 大鼠 |
| 收稿时间： | 2017/12/6 0:00:00 |
Effects of Modified Niduqing Mixture on renal interstitial fibrosis in rats with unilateral ureteral obstruction |
| |
| LI Yuqing,CHEN Meixue,ZHANG Xuefeng,DING Weiwei,ZHANG Zhongxian,FEI Desheng,LAN Xiaoqin and CHEN Di.Effects of Modified Niduqing Mixture on renal interstitial fibrosis in rats with unilateral ureteral obstruction[J].Shanghai Journal of Traditional Chinese Medicine,2018,52(7):96-101. |
| |
| Authors: | LI Yuqing CHEN Meixue ZHANG Xuefeng DING Weiwei ZHANG Zhongxian FEI Desheng LAN Xiaoqin and CHEN Di |
| |
| Affiliation: | Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China,Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China,Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China,Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China,Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China,Pinghu Mental Health Center,Pinghu 314200,China,Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China and Department of Nephrology,Pinghu Hospital of Traditional Chinese Medicine,Pinghu 314200,China |
| |
| Abstract: | |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《上海中医药杂志》浏览原始摘要信息 |
|
点击此处可从《上海中医药杂志》下载全文 |
|
