| 滋肾青芪颗粒对胶原诱导性关节炎小鼠的抗炎作用研究 |
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| 引用本文： | 程蕊林,顾军花,杨以阜,陈湘君,茅建春,周珺,邓予新,徐秋霞,陈文婷.滋肾青芪颗粒对胶原诱导性关节炎小鼠的抗炎作用研究[J].上海中医药杂志,2017,51(12):75-78. |
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| 作者姓名： | 程蕊林 顾军花 杨以阜 陈湘君 茅建春 周珺 邓予新 徐秋霞 陈文婷 |
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| 作者单位： | 上海中医药大学研究生院,上海,201203;上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学附属龙华医院风湿科,上海,200032,上海中医院大学科技实验中心病毒与免疫实验室,上海,201203,上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学研究生院,上海,201203;上海中医药大学附属龙华医院风湿科,上海,200032,上海中医药大学研究生院,上海,201203;上海中医药大学附属龙华医院风湿科,上海,200032 |
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| 基金项目： | 上海市卫计委进一步加快中医药事业发展三年行动计划项目(ZY3-JSFC-2-2004)；名老中医治疗SLE院内制剂滋肾青芪颗粒的新药临床前研究项目(14401971800) |
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| 摘 要： | 目的观察滋肾青芪颗粒对胶原诱导性关节炎小鼠的炎症预防及治疗作用。方法 DBA/1小鼠随机分为正常组,模型组,滋肾青芪颗粒低、中、高剂量组,甲氨蝶呤组。除正常组外,其余各组建立胶原诱导性关节炎小鼠模型,于攻击造模当天开始,连续给药3周。评定关节炎指数,观察小鼠关节病理切片炎性介质评分、骨破坏评分,ELISA法测定各组小鼠血清抗Ⅱ型胶原(CⅡ)特异性抗体水平。结果滋肾青芪各剂量组均可有效降低小鼠关节炎指数,与模型组比较差异有统计学意义(P0.05);滋肾青芪高剂量组能有效降低小鼠血清抗CⅡ的抗体滴度,与模型组比较差异有统计学意义(P0.05);滋肾青芪颗粒各组炎性介质评分、骨破坏评分均低于模型对照组(P0.05)。结论滋肾青芪颗粒对胶原诱导性关节炎小鼠关节炎具有预防治疗作用,其机制可能与降低关节炎小鼠血清中特异性抗血清CⅡ抗体水平有关。
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| 关 键 词： | 滋肾青芪颗粒 胶原诱导性关节炎 系统性红斑狼疮 抗炎 |
| 收稿时间： | 2017/7/28 0:00:00 |
Study on anti-inflammatory effects of Zishen Qingqi Granule in collagen-induced arthritis mice |
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| CHENG Ruiling,GU Junhu,YANG Yifu,CHEN Xiangjun,MAO Jianchun,ZHOU Jun,DENG Yuxin,XU Qiuxia and CHEN Wenting.Study on anti-inflammatory effects of Zishen Qingqi Granule in collagen-induced arthritis mice[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(12):75-78. |
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| Authors: | CHENG Ruiling GU Junhu YANG Yifu CHEN Xiangjun MAO Jianchun ZHOU Jun DENG Yuxin XU Qiuxia and CHEN Wenting |
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| Affiliation: | Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Laboratory of Virus and Immunology,Experiment Center for Science and Technology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China,Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China and Graduate School,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China |
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