大柴胡汤加减方对梗阻性黄疸术后患者肝功能、血流动力学及凝血功能的影响

目的:研究大柴胡汤加减方对梗阻性黄疸(梗阻性黄疸)术后患者肝功能、血流动力学及凝血功能的影响。方法:将150例梗阻性黄疸术后患者随机均分为观察组(n=75,大柴胡汤加减方辅助治疗)和对照组(术后常规治疗)进行治疗,疗程7天,比较两组临床疗效以及患者肝功能、血流动力学、凝血功能指标。结果:两组有效率分别为97.33%和89.33%(P<0.05),观察组治疗效果优于对照组,差异有统计学意义(P<0.05);治疗后,两组TBIL和DBIL均随时间降低,组内不同时间点差异有统计学意义(P<0.05),观察组治疗第3天和第7天时TBIL和DBIL均低于对照组,差异有统计学意义(P<0.05);治疗后,两组血清ALT、AST水平明显降低(P<0.05),ALB、CHE明显升高(P<0.05),且观察组ALT、AST低于对照组,ALB、CHE高于对照组,差异有统计学意义(P<0.05);治疗后,两组ESR明显上升(P<0.05),HCT、全血黏度及血浆黏度明显降低(P<0.05),且观察组ESR高于对照组,HCT、全血黏度及血浆黏度低于对照组,差异有统计学意义(P<0.05);治疗后,两组APTT、PT及FIB水平明显降低(P<0.05),PLT水平明显升高(P<0.05),且观察组APTT、PT及FIB低于对照组,PLT高于对照组,差异有统计学意义(P<0.05)。结论:大柴胡汤加减方辅助治疗梗阻性黄疸有利于促进黄疸消退,减轻患者症状,促进肝功能恢复,同时可降低血液黏度,改善凝血功能,从而提升临床疗效。

Effect of Dachaihu Decoction on Liver Function,Hemodynamics and Coagulation Function for Postoperative Patients with Obstructive Jaundice

Objective:To study the effect of Dachaihu Decoction on liver function,hemodynamics and coagulation function for postoperative patients with obstructive jaundice.Methods:150 cases of postoperative patients with obstructive jaundice were randomly divided into observation group(n=75,Dachaihu Decoction adjuvant therapy)and controlled group(postoperative routine treatment),and they were treated for 7 days.The clinical efficacy,liver function,hemodynamics and coagulation function indicatorswere compared between the two groups.Results:The effective rates in the two groups were 97.33%and 89.33%respectively(P<0.05),and the treatment effects in the observation group were better than those in the controlled group(P<0.05).After treatment,the TBIL and DBIL in the two groups were decreased with time,and there were significant differences at different time points between the groups(P<0.05).The TBIL and DBIL in the observation group were lower than those in the controlled group on the 3 rd and 7 th day of treatment(P<0.05).After treatment,the serum ALT and AST in the two groups were significantly decreased(P<0.05)while the ALB and CHE were significantly increased(P<0.05),and ALT and AST in the observation group were lower than those in the controlled group while ALB and CHE were higher than those in the controlled group(P<0.05).After treatment,the ESR in the two groups was increased significantly(P<0.05),HCT,whole blood viscosity and plasma viscosity decreased significantly(P<0.05),and the ESR of the observation group was higher than the controlled group while HCT,whole blood viscosity and plasma viscosity were lower than those in the controlled group(P<0.05).After treatment,the level of APTT,PT and FIB were significantly decreased(P<0.05)while the PLT level was significantly increased(P<0.05),and the APTT,PT and FIB in observation group were lower than those in control group(P<0.05).Conclusion:Using Dachaihu Decoction in the adjuvant treatment of obstructive jaundice is beneficial to promote the regression of jaundice,reduce the symptoms,promote the recovery of liver function,and reduce blood viscosity and improve blood coagulation function,thus improving clinical efficacy.