独活寄生合剂对老年膝骨关节炎核磁共振成像积分和血清软骨代谢标志物的影响

目的:探讨独活寄生合剂对老年膝骨关节炎(KOA)患者全膝关节核磁共振成像积分(WORMS)和血清中软骨代谢标志物的影响,观察独活寄生合剂治疗老年KOA的临床疗效。方法:选取KOA患者80例,随机分成对照组和治疗组,各40例。对照组予以盐酸氨基葡萄糖胶囊口服;治疗组加用独活寄生合剂口服,均治疗8周。观察治疗前后Western Ontario and Mc Master Universities(WOMAC)量表评分变化;用WORMS积分进行放射学疗效评估;酶联免疫吸附(ELISA)法检测治疗前后血清中软骨代谢标志物软骨寡聚基质蛋白(COMP)和蛋白聚糖水平。结果:治疗组总有效率(86.84%)明显高于对照组(71.79%)(P0.05);与治疗前比较,两组WOMAC评分改善,膝关节WORMS积分减少,COMP和蛋白聚糖含量降低,差异均具有统计学意义(P0.05);且治疗组优于对照组(P0.05)。结论:独活寄生合剂可有效缓解老年性KOA临床症状,改善膝关节影像学损害,降低软骨代谢标志物含量而保护KOA软骨。

Effects of Duhuo Jisheng Mixture on WORMS and Cartilage Metabolism Markers in Serum of Elderly with KOA

Objective: To observe the effects of Duhuo Jisheng mixture on whole-organ magnetic resonance imaging scores (WORMS) and cartilage metabolism markers in serum of elderly patients with knee-joint osteoarthritis (KOA), and investigate its clinical efficacy for elderly KOA. Method: Totally 80 elderly patients with KOA were randomly divided into control group (40 cases) and treatment group (40 cases). Patients in control group orally took hydrochloric acid glucosamine capsules, and patients in treatment group also orally took Duhuo Jisheng mixture based on the treatment of control group. The treatment course was 8 weeks for both groups. Western Ontario and McMaster Universities(WOMAC) scores before and after treatment of the two groups were observed, radiographic efficacy was assessed with WORMS scores, cartilage oligomeric protein (COMP) and proteoglycan levels of cartilage metabolism markers in serum were detected by enzyme linked immunosorbent assay (ELISA). Result: The total effective rate in the treatment group was 86.84%, significantly higher than 71.79% in control group(P < 0.05). As compared with the conditions before treatment, WOMAC scores were improved in both groups, WORMS scores of knees were reduced, COMP and proteoglycan levels were reduced (P < 0.05). The effect in treatment group was better than that in control group (P < 0.05). Conclusion: Duhuo Jisheng mixture can effectively relieve the clinical symptoms of elderly KOA, improve the knee imaging damages and reduce content of cartilage metabolism markers, thus protect the cartilage in patients with KOA.