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独活寄生汤治疗膝骨关节炎临床观察
引用本文:余建华,张衡.独活寄生汤治疗膝骨关节炎临床观察[J].中国实验方剂学杂志,2010,16(6).
作者姓名:余建华  张衡
作者单位:洛阳市第三人民医院风湿免疫科,河南 洛阳 471002;洛阳市第三人民医院风湿免疫科,河南 洛阳 471002
摘    要:目的: 观察独活寄生汤治疗膝骨关节炎(OA)的疗效。 方法: 选择符合纳入标准患者113例,随机分为治疗组和对照组,治疗组56例给予独活寄生汤治疗,对照组57例给予硫酸氨基葡萄糖(GS)治疗,疗程均为4周。采用 Lequesne的OA疼痛功能指数对膝关节的症状体征和功能活动进行评分。 结果: 总有效率治疗组为96.43%,对照组为82.45%,两组比较差异有显著性(P<0.05),治疗组优于对照组。治疗后两组疼痛功能指数评分均有显著降低,治疗前后比较,差异非常显著(P<0.001),治疗组评分降低优于对照组(P<0.001)。停药4周后对照组疗效明显降低(与疗程结束时比较P<0.01),而治疗组疗效降低不明显(与疗程结束时比较P>0.05)。 结论: 独活寄生汤治疗膝OA疗效明显优于GS组的疗效,且具有较好的安全性。

关 键 词:独活寄生汤  骨关节炎  膝关节  中医药疗法

Duhuo Jisheng Tang of Knee Osteoarthritis Clinical Observation
YU Jian-hua and ZHANG Heng.Duhuo Jisheng Tang of Knee Osteoarthritis Clinical Observation[J].China Journal of Experimental Traditional Medical Formulae,2010,16(6).
Authors:YU Jian-hua and ZHANG Heng
Abstract:Objective: To research the effect and drug resistance of Duhuo Jisheng Tang on knee osteoarthritis (OA). Method: Select 113 patients met the inclusion criteria Were randomly divided into two groups. Patients in treatment group (n=56) were treated with Duhuo Jisheng Tang. Patients in control group (n=57) were treated with Glucosamine sulfate. The therapeutic course was 4 weeks in both groups. Based on Lequesne function index of OA pain evaluation of Signs and symptoms of knee joint functional activities. Result: The total effective 96.43% in treatment group,82.45% in control group, between two groups the differences were statistically significant(P<0.05),The treatment group Superior than the control group.two groups after treatment the Pain and functional index score were significantly lower, before and after treatment, the differences were statistically significant (P<0.001), The treatment group score lower than the control group, the difference was statistically significant (P<0.001).After 4 weeks of withdrawal efficacy of the control group significantly decreased (compared with the end of treatment, P<0.01), while the treatment group was not significantly lower efficacy (compared with the end of treatment, P>0.05). Conclusion: Duhuo Jisheng Tang effect of knee osteoarthritis is superior to the efficacy of Glucosamine sulfate,and has good security.
Keywords:Duhuo Jisheng Tang  osteoarthritis  knee joint  Chinese medicine treatment
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