| 黄连的化学成分研究 |
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| 引用本文： | 王琦,李志峰,陈刚,冯育林,范玫玫,裴月湖.黄连的化学成分研究[J].中国实验方剂学杂志,2012,18(7):74-76. |
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| 作者姓名： | 王琦 李志峰 陈刚 冯育林 范玫玫 裴月湖 |
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| 作者单位： | 1. 中药固体制剂制造技术国家工程研究中心,南昌 330006;江西中医学院,南昌 330006
2. 沈阳药科大学中药学院,沈阳,110016 |
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| 基金项目： | 国家自然科学基金项目(30873368) |
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| 摘 要： | 目的:研究毛茛科植物黄连Coptis chinensis的化学成分.方法:利用柱色谱、凝胶柱色谱、高效液相色谱等各种色谱技术对黄连的95％进行分离,根据其所得化合物的理化性质与UV,IR,MS,NMR等光谱数据鉴定其结构.结果:从黄连的95％乙醇提取物的氯仿萃取部分分离得到7个已知成分,分别鉴定为香草酸(1),落叶松树脂醇(2),原儿茶酸乙酯(3),小檗碱(4),丹参素甲酯(5),反式阿魏酰基酪胺(6),氧化小檗碱(7).结论:其中,化合物(3),(5),(6)为首次从该属植物中分离得到.
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| 关 键 词： | 结构鉴定 柱色谱法 黄连 氯仿提取物 |
| 收稿时间： | 5/6/2011 12:00:00 AM |
Chemical Constituents from Coptis Chinensis Franch |
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| WANG Qi,LI Zhi-feng,CHEN Gang,FENG Yu-lin,FAN Mei-mei and PEI Yue-hu.Chemical Constituents from Coptis Chinensis Franch[J].China Journal of Experimental Traditional Medical Formulae,2012,18(7):74-76. |
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| Authors: | WANG Qi LI Zhi-feng CHEN Gang FENG Yu-lin FAN Mei-mei and PEI Yue-hu |
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| Affiliation: | National Pharmaceutical Eengineering Center For Solid Preparation in Chinaese Herbal Medicine, Nanchang 330006, China; Jiangxi University of Traditional Chinaese Medicine, Nanchang 330006, China;National Pharmaceutical Eengineering Center For Solid Preparation in Chinaese Herbal Medicine, Nanchang 330006, China; Jiangxi University of Traditional Chinaese Medicine, Nanchang 330006, China;School of Traditional Chinaese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;National Pharmaceutical Eengineering Center For Solid Preparation in Chinaese Herbal Medicine, Nanchang 330006, China; Jiangxi University of Traditional Chinaese Medicine, Nanchang 330006, China;National Pharmaceutical Eengineering Center For Solid Preparation in Chinaese Herbal Medicine, Nanchang 330006, China; Jiangxi University of Traditional Chinaese Medicine, Nanchang 330006, China;School of Traditional Chinaese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective:Aim To study the chemical constituents of Co.chinensis Franch.Method: The compounds were separated and purified by column chromatography and their structures were established by spectroscopic methods.Result: Seven compounds were isolated from the chloroform extract of C.chinensis Franch,whose structures were determined as(1),vanillic acid(1),lariciresinol(2),protocatechuic acid ethyl ester(3),berberine(4),3,4,α-trihydroxy-methyl phenylpropionate(5),N-tran-feruloyltyramine(6),Oxyberberine(7).Conclusion: Compounds 3,5,6were isolated from this genus for the first time. |
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| Keywords: | structural identification column chromatography Coptis chinensis chloroform extract |
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