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射干麻黄汤治疗小儿咳嗽变异性哮喘的系统评价及Meta分析
引用本文:陈照南,惠萍,宋天云,黄崇政.射干麻黄汤治疗小儿咳嗽变异性哮喘的系统评价及Meta分析[J].中国实验方剂学杂志,2012,18(19):1-4.
作者姓名:陈照南  惠萍  宋天云  黄崇政
作者单位:1. 广东省江门市五邑中医院,广东江门,529000
2. 湖南省永州市中医院,湖南永州,425000
摘    要:目的:运用循征医学方法对射干麻黄汤治疗小儿咳嗽变异性哮喘进行系统评价.方法:计算机检索中国知网,维普数据库,万方数据库,同时手检相关杂志专业资料.结果:共查及文献94篇,7篇符合纳入标准,采用Jadad评分标准对每篇文章的方法学质量进行评价,属低质量文献,共收入病人470例,总优势比(OR) =2.99,95%置信区间(CI)为(1.90 ~4.71),合并效应检验Z=4.71 (P <0.000 01),差异有统计学意义.结论:现有临床证据表明,射干麻黄汤治疗小儿咳嗽变异性哮喘有效.但系统评价纳入的随机对照临床试验均属低质量文献,其疗效须进一步开展大规模的高质量临床试验研究来验证.

关 键 词:射干麻黄汤  小儿咳嗽变异性哮喘  系统评价  Meta分析
收稿时间:4/8/2012 12:00:00 AM

Systematic Reviews and Meta Analysis of Cough Variant Asthma in Children with Shegan Mahuang Tang
CHEN Zhao-nan,HUI Ping,SONG Tian-yun and HUANG Chong-zheng.Systematic Reviews and Meta Analysis of Cough Variant Asthma in Children with Shegan Mahuang Tang[J].China Journal of Experimental Traditional Medical Formulae,2012,18(19):1-4.
Authors:CHEN Zhao-nan  HUI Ping  SONG Tian-yun and HUANG Chong-zheng
Affiliation:1.Guangdong Jiangmen Wuyi Tradition Chinese Medicine(TCM) Hospital,Jiangmen 529000,China; 2.Hunan Yongzhou TCM Hospital,Yongzhou 425000,China)
Abstract:Objective:Evidence Based Medicine (EBM) is used to do systematic reviews on Shegan Mahuang tang (Ephedra decoction) controlling cough variant asthma (CVA) in children. Method:Data retrieval is done on the websites such as cnki, cqvip, wanfangdata and offline professional magazines. Result:Ninty-four pieces of literatures are attained and 7 pieces accord with the inclusive criteria. Jadad Criteria is adopted to assess every literature's Methodological quality, all of which are low quality ones. 470 cases are obtained. OR=2.99, 95% CI of 1.90 to 4.71, test for overall effect:Z=4.71(P<0.000 01). Therefore, the difference is statistically significant. Conclusion:The existed clinical evidences shows, Shegan Mahuang tang is effecitve to control cough variant asthma (CVA) in children. However, randonmized control clinical trials are subsumed by systematic reviews belong to low quality ones, so Shegan Mahuang tang's therapeutic effect need to be further examined by a large scale of high quality of clinical trials.
Keywords:Shegan Mahuang tang (Ephedra decoction)  cough variant asthma (CVA) in children  systematic reviews  Meta analysis
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