| 精制抗放射性肺炎方的等效性研究 |
| |
| 引用本文： | 欧瑶,李曙光,陈不尤,周士忠,肖明兵,江枫,钱霞,陆亚鹏.精制抗放射性肺炎方的等效性研究[J].中国实验方剂学杂志,2013,19(15):227-231. |
| |
| 作者姓名： | 欧瑶 李曙光 陈不尤 周士忠 肖明兵 江枫 钱霞 陆亚鹏 |
| |
| 作者单位： | 1. 南通大学附属医院,江苏南通,226001
2. 南通大学海洋医学研究所,江苏南通,226001 |
| |
| 基金项目： | 江苏省南通市社会发展计划(S2008035) |
| |
| 摘 要： | 目的:观察抗放射性肺炎方(anti-radiation pneumonia decoction,ARPD)水提醇沉精制液和水煎剂治疗放射性肺损伤的等效性.方法:采用水提醇沉法初步精制ARPD水煎剂.将60只大鼠随机分为模型组、水煎剂组、精制液组和正常对照组.前3组均行直线加速器6MVX射线17Gy全胸单次照射.照射后每日分别给予ig生理盐水、ARPD水煎剂和精制液各35 g·kg-1,1次/d,每次10 mL·kg-1.各组大鼠分别于照射后第7,15,30,45,60天观察和取材,检测肺组织和血清中超氧化物歧化酶(SOD)、丙二醛(MDA)和羟脯氨酸(HYP)含量.结果:①模型组大鼠肺组织病理检查发现炎症改变及胶原增生,肺组织和血清SOD活力下降,而MDA和HYP升高,与同期对照组比有显著差异(P＜0.01)；②ARPD水煎剂组、精制液组两组肺组织病理检查炎症改变及胶原增生明显轻于同期模型组,两中药间无明显差异；③SOD活力下降,MDA和HYP升高,模型组甚于水煎剂组和精制液组(P＜0.01),两中药制剂间无显著差异.结论:①早期应用ARPD可以明显减轻肺的放射性炎症反应,降低肺纤维化的程度；②ARPD精制液和水煎剂的抗放射性肺损伤疗效相当；③水提醇沉法是ARPD纯化精制的可行的工艺方法.
|
| 关 键 词： | 放射性肺损伤 抗放射性肺炎方 精制液 等效性 |
| 收稿时间： | 2013/3/22 0:00:00 |
Comparison of Therapeutic Effects between the Refined Extract and Crude Aquatic Solution of Anti-radiation Pneumonia Decoction |
| |
| OU Yao,LI Shu-guang,CHEN Bu-you,ZHOU Shi-zhong,XIAO Ming-bing,JIANG Feng,QIAN Xia and LU Ya-peng.Comparison of Therapeutic Effects between the Refined Extract and Crude Aquatic Solution of Anti-radiation Pneumonia Decoction[J].China Journal of Experimental Traditional Medical Formulae,2013,19(15):227-231. |
| |
| Authors: | OU Yao LI Shu-guang CHEN Bu-you ZHOU Shi-zhong XIAO Ming-bing JIANG Feng QIAN Xia and LU Ya-peng |
| |
| Affiliation: | Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Affiliated Hospital of Nantong University, Nantong 226001, China;Institue of Nautical Medicine, Nantong University, Nantong 226001, China |
| |
| Abstract: | |
| |
| Keywords: | radiation-induced lung injury anti-radiation pneumonia decoction refined extract equivalence study |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中国实验方剂学杂志》浏览原始摘要信息 |
|
点击此处可从《中国实验方剂学杂志》下载全文 |
|
