抗急性痛风性关节炎天然产物药理研究进展

通过查阅近几年有关天然产物及其有效成分抗急性痛风性关节炎的药理作用及其机制相关研究的文献报道,围绕尿酸盐结晶所致急性痛风性关节炎动物模型的发病机制,对天然产物及其有效成分抗急性痛风性关节炎作用靶点和药理作用机制进行文献整理、分析和归纳。研究表明,抗急性痛风性关节炎的天然产物有效成分主要有黄酮类、生物碱类、多酚类、皂苷类、香豆素类等,通过抗炎、镇痛、抑制相关炎症介质的释放及其信号通路、抗氧化等作用机制及多个药物作用靶点发挥抗急性痛风性关节炎的作用。治疗急性痛风性关节炎的西药作用靶点较单一,存在较严重副作用,不利于控制急性痛风性关节炎的发复发作。中医运用天然药物防治急性痛风性关节炎拥有上千年历史和经验,与西药相比,抗急性痛风性关节炎天然药物具有多靶点,低毒副作用的优势,近年来越来越多的科研工作者运用实验药理学和分子生物学方法来研究天然产物及其有效成分抗急性痛风性关节炎的作用,并取得喜人的研究成果。

Review on Pharmacological Activities of Natural Products Against Acute Gouty Arthritis

Acute gouty arthritis (AGA) is a crystal joint disease caused by uric acid crystal deposition in the joints which was caused by purine metabolic disorder. By reviewing the literature reports in recent years on pharmacological effects and mechanism of natural products and their effective components against AGA, and focusing on the pathogenesis of urate crystal-induced acute gouty arthritis in animal models, we collected,summarized and analyzed the literature on targets and pharmacological action mechanism of natural products and their effective components against acute gouty arthritis. Studies have shown that the main effective components in natural products against acute gouty arthritisinclude flavonoids, alkaloids, polyphenols, saponins, and coumarin, etc. They fight against the acute gouty arthritis through anti-inflammatory, analgesic and inhibiting the release of inflammatory mediators as well as its related signaling pathways, antioxidant mechanism and multiple drug targets. Targets for the treatment of acute gouty arthritis are single in western medicine, with more serious side effects, thus not conducive to control the recurrence of acute gouty arthritis. Natural products in traditional Chinese medicines have a thousand years of history and experience in prevention and treatment of acute gouty arthritis. Compared with the western medicine, natural medicine has shown great potential and advantages of multiple targets and few side effects for the acute gouty arthritis. In recent years, more and more researchers use experimental pharmacology and molecular biology method to study the effect of natural products and their effective components against acute gouty arthritis, and have achieved gratifying results.