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中药有效成分治疗血管性痴呆的研究进展
引用本文:韩飞,荆志伟,于亚南,刘骏,王忠.中药有效成分治疗血管性痴呆的研究进展[J].中国实验方剂学杂志,2012,18(7):273-276.
作者姓名:韩飞  荆志伟  于亚南  刘骏  王忠
作者单位:中国中医科学院中医临床基础医学研究所,北京,100700
基金项目:国家"十一五"科技重大专项项目(2009ZX09301-005)
摘    要:作为中药复方的效应单元,单味中药及其有效成分在防治血管性痴呆(VD)方面具有选择性高、针对性强等特点,故单味中药的研究越来越受到重视.涉及补虚类(人参、何首乌、刺五加、黄芪、红景天)、活血化瘀类(银杏、丹参、川芎、姜黄、灯盏花)、清热类(黄芩、知母、地黄、栀子)及其他类(千层塔、葛根、丁香).其作用机制主要有:①增加ATP酶等活性物质含量,抑制氧化应激;②调节脑内胆碱能系统相关蛋白、基因、神经递质表达;③抑制肾素-血管紧张素系统、减少钙内流、防止自由基形成造成的神经元损伤等.补虚类和活血化瘀类中药治疗VD研究较多.中药有效成分作用多途径、多靶点,干预了VD病理生理过程的多个环节,为促进临床用药及中药新药研发提供方向,同时提出当前研究中存在的问题,期待深入研究.

关 键 词:血管性痴呆  实验研究  中药有效成分  中医药疗法
收稿时间:2011/8/24 0:00:00

Process on Experimental Studies of Active Ingredients of Traditional Chinese Medicine for Vascular Dementia
HAN Fei,JING Zhi-wei,YU Ya-nan,LIU Jun and WANG Zhong.Process on Experimental Studies of Active Ingredients of Traditional Chinese Medicine for Vascular Dementia[J].China Journal of Experimental Traditional Medical Formulae,2012,18(7):273-276.
Authors:HAN Fei  JING Zhi-wei  YU Ya-nan  LIU Jun and WANG Zhong
Affiliation:Institute of Basic Research in Clinical Medicine in China Academy of Chinaese Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medicine in China Academy of Chinaese Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medicine in China Academy of Chinaese Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medicine in China Academy of Chinaese Medical Sciences, Beijing 100700, China;Institute of Basic Research in Clinical Medicine in China Academy of Chinaese Medical Sciences, Beijing 100700, China
Abstract:Single herb and its active ingredients have a high selectivity and specific characteristics in the prevention and treatment of vascular dementia(VD),so more and more attention have been paid to the studies on single herb and its active ingredients.These studies mainly focus on the following kinds of herbs,such as: herbs with tonic effects Ginseng Radix et Rhizoma,Polygoni Multiflori Radix,Acanthopanacis Senticosi Radix et Rhizoma Seu Caulis,Astragali Radix,Rhodiolae Crenulatae Radix et Rhizoma,herbs wtih blood circulation-activating and stasis-dissolving effect Ginkgo Folium,Salviae Miltiorrhizae Radix et Rhizoma,Chuanxiong Rhizoma,Curcumae Longae Rhizoma,Erigerontis Herba,herbs with Heat-clearing effect Astragali Radix,Anemarrhenae Rhizoma,Rehmanniae Radix,Gardeniae Fruetus,and other types Lycopodium serratum Thunb.,Puerariae Lobatae Radix,Caryophylli Flos.Their efficacy mechanisms are mostly involved in: ①increasing the active material(for example ATP enzyme) to restrain from oxidative stress(OS).②promoting the activity of the cerebral cholinergic system,such as protein,gene and so on.③inhibiting the renin-angiotensin system,calcium influx and the metabolism of free radicals to prevent neurons from cerebral damage.It was concluded that most studies on the treatment of VD were related to herbs with tonic effects or with blood circulation-activating and stasis-dissolving effects,and these herbs and their active ingredients showed wider effect-profiles on VD through regulating diverse pathological or physiological pathways of VD.These findings may provide useful information for future research and development of new drugs and clinical application in the treatment for VD.
Keywords:vascular dementia  experiment study  active ingredients of traditional Chinese medicine  Chinese medical treatment
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