冠脉通胶囊对大鼠实验性血栓的影响

目的:研究冠脉通胶囊对大鼠实验性血栓的影响.方法:取60只SPF级Wistar大鼠随机分为模型组、冠脉通胶囊低、中、高剂量组(0.67,1.34,2.68 g?kg-1)、冠心丹参胶囊组(0.24 g?kg-1)、吲哚布芬片组(0.04 g?kg-1),ig给药7d,末次给药30 min后麻醉剥离颈总动脉,采用直流电刺激法造成血栓模型,结扎血栓两侧,剪下称量血栓质量,统计平均阻塞率.结果:冠脉通胶囊低、中、高剂量组平均阻塞率( 40.25％,37.11％,39.05％)与模型组平均阻塞率(50.99％)比明显降低(P＜0.05,P＜0.05,P＜0.01),同时低、中、高剂量组血栓质量(0.001 9,0.001 7,0.001 5 g)与模型组血栓质量(0.002 6 g)比明显减少(P ＜0.05,P＜0.05,P＜0.01),并且具有量效关系.结论:冠脉通胶囊具有抵抗血栓生成的作用.

Effect of Guanmaitong Capsules on Experimental Thrombogenesis in Rats

Objective: To study the Guanmaitong capsules(GMT) on the experimental thrombosis. Method: Sixty SPF Wistar rats were randomly divided into six groups:the normal control group, GMT groups(0.67,1.34,2.68 g·kg^-1, ig),Guanxindanshen capsules group(0.24 g·kg^-1,ig)and indobufen tablets group(0.04 g·kg^-1,ig).The experimental thrombosis model was induced by electric stimulation.Rats need to take medicine seven days.After thirty minutes of the last one, we should strip the carotid artery and ligate the two sides of thrombus. Weighting the weight of thrombus and statistics the average blocking rate would be done. Result: Compared with the noamal control group(50.99%)and(0.002 6 g), the average thromboembolism rate of GMT(40.25%,39.05%,37.11%) and the weight of thrombus( 0.001 9,0.001 7,0.001 5 g)could significantly decrease(P<0.05,P<0.05,P<0.01). meanwhile existing the quantity-efficiency relations. Conclusion: The results showed that GMT could decrease the weight of the thrombus.