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| 双氢青蒿素软膏处方筛选及体外渗透性研究 | |
| 引用本文： | 杜丰,李荣生,王乃婕,邱琳,张蓓,梁秉文,付桂兰,叶祖光.双氢青蒿素软膏处方筛选及体外渗透性研究[J].中国中医药信息杂志,2008,15(9):49-50. |
| 作者姓名： | 杜丰 李荣生 王乃婕 邱琳 张蓓 梁秉文 付桂兰 叶祖光 |
| 作者单位： | 1. 中药复方新药开发国家工程研究中心,北京,100075;贵阳中医学院,贵州,贵阳,550002 2. 中国中医科学院实验药厂,北京,100700 3. 中药复方新药开发国家工程研究中心,北京,100075 |
| 摘 要： | 目的筛选双氢青蒿素（DHA）软膏处方及促渗剂。方法建立体外经皮渗透试验方法，采用高效液相色谱法对DHA样品的体外透皮速率进行考察，并以DHA累积透过量作体外透皮曲线，与Higuchi方程进行拟合。结果透皮速率以卡波普水溶性软膏及促渗剂为氮酮的最高，达到27．262μg／（h·cm），Higuchi方程线性较好。结论最佳处方为卡波普水溶性基质的DHA软膏处方，最佳促渗剂为氮酮。 |
| 关 键 词： | 双氢青蒿素 软膏 体外透皮试验 促渗剂 高效液相色谱法 |
Preparation and In Vitro Permeability Study of Dihydroartemisinin Ointment |
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| DU Feng,LI Rong-sheng,WANG Nai-jie,et al.Preparation and In Vitro Permeability Study of Dihydroartemisinin Ointment[J].Chinese Journal of Information on Traditional Chinese Medicine,2008,15(9):49-50. | |
| Authors: | DU Feng LI Rong-sheng WANG Nai-jie |
| Affiliation: | DU Feng1,2,LI Rong-sheng3,WANG Nai-jie1,et al (1.State Research Center for Research , Development of TCM Multi-ingredient Drugs,Beijing 100075,China,2.Guiyang College of TCM,Guiyang 550002,3.Experimental Pharmaceutical Company of China Academy of Chinese Medical Sciences,Beijing 100700,China) |
| Abstract: | Objective To optimize the formulation of Dihydroartemisinin ointment and study its characteristics of penetration enhancers. Method A method of transdermal experiment in vitro was established for DHA. The penetration rate in vitro was examined by HPLC, and coincided the DHA cumulative permeation curve with the Higuchi equation. Result The penetration rate of DHA from DHA ointment made up of water-soluble carbopol and Azone was the highest in all formulations, up to 27.262 pg/（h · cm^2）. The cumulative permeation curve which coincided with the Higuchi equation was better. Conclusion The formulation which made up of water-soluble carbopol and Azone was optimized. |
| Keywords: | Dihydroartemisinin ointment transdermal experiment in vitro penetration enhancers HPLC |
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