雷公藤多甙对男子尿β2－微球蛋白的影响

 本研究对１２名３５～４０岁的男性轻型银屑病患者，每日口服雷公藤多甙２０ｇ（抗生育有效剂量，为临床常用剂量的１／３～１／４）。在用药前、用药３个月及停药后３个月采集尿液标本，用酶－免疫法测定尿液β＿２－微球蛋白的含量。结果表明：用药前尿β＿２－微球蛋白的含量平均为１４２．１±６．４μｇ／Ｌ，用药３个月尿β＿２－微球蛋白的平均含量为３３７．３±９．８μｇ／Ｌ，比用药前明显升高（Ｐ＜０．０５）。停药后３个月尿凡．檄球蛋白的平均含量为３４３．６±８．４μｇ／Ｌ，同用药３个月相比，差异无显著性意义（Ｐ＞０．０５），与用药前相比，差异有显著性意义（Ｐ＜０．０５）。

The effect of glycosides of(Tripterygium wilordii)on urine β_2-microglu-bin of men

fertil men with mild psoriasis requiring glycosides of Tripterygium wilfordiiHook.F。(GTW)treatment were given GTW 20 mg/day (antifertility dose,1/3 of the regulartherapeutic dose) orally for 3 months。 Their urine samples were collected before GTW treatment,3months after treatment,and 3 months after withdrawal of treatment.The urineβ_2-microglubinconcentration was detected byβ_2-Micro Test Enzyme Immuno Assay。The mean concentration ofurine β_2-microglubin was 142.1±6.4 μg/L.before treatmen,337.3±9.8 μg/L after treatment,and 343.6±8.3μg/L after withdrawal of treatment respectively。 Compared with before treat-ment,the urine β_2-microglubin level was significantly increased after treatment(P<0.05)andwithdrawal of treatment(P<0.05 );