中药枸骨叶脂溶性化学成分的研究

 目的研究中药枸骨叶(Ilexcornuta)的脂溶性化学成分,为其抗动脉粥样硬化活性寻找可能的先导化合物。方法利用硅胶和SephadexIH-20等柱色谱进行分离,用化合物的波谱数据鉴定其结构。结果从枸骨叶的氯仿部位分得11个脂溶性成分,其中包括7个三萜类成分即羽扇豆醇(1),11-酮基-α-香树脂醇棕榈酸酯(Ⅱ),α-香树脂醇棕榈酸酯(Ⅲ),3,28-乌索酸二醇(Ⅳ),熊果酸(Ⅴ),30-醛基羽扇豆醇(Ⅵ),30-酮基降羽扇豆醇(Ⅶ);1个链状倍半萜tanacetene(Ⅷ);1个甾醇β-谷甾醇(Ⅸ),2个有机酸类成分即正二十二烷酸(Ⅹ)和正二十六烷(Ⅺ)。结论化合物Ⅳ,Ⅶ,Ⅷ,Ⅹ和Ⅺ为首此从冬青属植物中分得,化合物Ⅱ,Ⅲ和Ⅸ为首次从该植物中分得。倍半萜类成分为首此从冬青属植物中分得的化合物类型。

Liposoluble components from leaves of Ilex cornuta

OBJECTOVE To investigate the liposoluble components from the leaves of llex comuta Lindl. ex Paxt.. METHODS The compounds were isolated by repeated column chromatography on silica gel and Sephadex LH-20, and the structures were elucidated by spectral analysis. RESULTS Eleven compounds were obtained. Their structures were identified as lupeol(Ⅰ), 11-keto-α-amyrin pahlmitate(Ⅱ), α-amyrin palmitate(Ⅲ), 12-ursene-3,28-diol(Ⅳ), ursolic acid(Ⅴ), 3β-hydroxylup-20(29)-en-30-al(Ⅵ), 3β-hydroxy-20-oxo-30-norlupane(Ⅶ), tanacetene(ⅧA),β-sitosterol (Ⅸ), n-behenic acid(Ⅹ), and n-hexacosane (Ⅺ). CONCLUSION Compound Ⅳ, Ⅶ, Ⅷ, Ⅹ and Ⅸ are firstly isolated from the genus Ilex. In addition, compound Ⅱ, Ⅲ and Ⅸ are isolated from I. comuta for the first time.