淀粉微凝胶对阿司匹林片体外释药的影响

 目的研究淀粉微凝胶对阿司匹林片体外释药的影响。方法采用释放度测定第一法,分别考察不同条件下阿司匹林淀粉微凝胶片的释放度。结果随着微凝胶含量的增加,阿司匹林片的释药速率逐渐下降,相应的释药模型分别为:双指数双相动力学y=100-94.66e^-0.601t-7.24e^-0.0075t和y=100-67.7e^-0.355t-3205e^-0.103t,单指数宏观单相动力学y=100-101e^-0.157t,骨架溶蚀动力学y=8.6t^0.894;随温度和pH值升高,释药速率显著性提高。结论增大微凝胶含量可改变阿司匹林片的释药规律,延长药物释放时间;淀粉微凝胶片具有温度和pH双重敏感性,可实现对人体的温度、化学环境等异常变动自动感知、自动释药。

Effect of Starch Microgels on Aspirin Release from Tablets in vitro

OBJECTIVE To study the effect of starch microgels on aspirin release from aspirin tablets in vitro. METHODS The drug release under different conditions was researched by the method published in China Pharmacopoeia 2005.RESULTS The drug release velocity decreased with the increase of amount of the microgels, and the drug release processes accorded with double exponential diphase kinetics equation y=100-94.66e~ -0.601t -7.24 e~ -0.007 5t and y=100-67.7e~ -0.355t -32.5 e~ -0.103t ,single-exponential macroscopically single-phase kinetics equation y=100-101 e~ -0.157t ,matrix corrosion kinetics equation y=8.6 t~ 0.894 . The release velocity increased with the increase of temperature and pH value. CONCLUSION The drug release rule of aspirin starch microgels tablets depended on the content of the microgels in the tablet, as so as the drug release time. The tablets were both sensitive to temperature and pH, and they could release drug in terms of the abnormal change of temperature and chemical surroundings in human body.