| 类风湿关节炎骨破坏及其针灸治疗的骨免疫学机制研究现状 |
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| 引用本文： | 王洋洋,徐媛,苑功名,康丽娟,吕伟,郭永明.类风湿关节炎骨破坏及其针灸治疗的骨免疫学机制研究现状[J].山东中医杂志,2022(3):343-347. |
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| 作者姓名： | 王洋洋 徐媛 苑功名 康丽娟 吕伟 郭永明 |
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| 作者单位： | 天津中医药大学实验针灸学研究中心;天津中医药大学针灸推拿学院;国家中医针灸临床医学研究中心 |
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| 基金项目： | 国家自然科学基金面上项目(编号:81873368)。 |
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| 摘 要： | 免疫系统和骨骼系统共享多种信号通路和细胞因子，并通过免疫细胞与骨组织细胞相互连接，骨免疫学的主要内容即是研究两者之间相互作用的复杂关系，类风湿关节炎骨破坏的机制亦在于此。针灸具有良好的抗炎镇痛、调节免疫与内分泌、改善微循环等作用，其治疗类风湿关节炎骨破坏的机制主要包括调节破骨细胞、调节NF-κB受体激活蛋白配体（RANKL）-RANK-骨保护素（OPG）通路、调节炎症因子等。参考文献35篇。
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| 关 键 词： | 骨免疫学 类风湿关节炎 骨破坏 针灸 |
Research Status of Rheumatoid Arthritis Bone Destruction and Acupuncture Intervention Mechanism Based on Osteoimmunology |
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| WANG Yangyang,XU Yuan,YUAN Gongming,KANG Lijuan,LYU Wei,GUO Yongming.Research Status of Rheumatoid Arthritis Bone Destruction and Acupuncture Intervention Mechanism Based on Osteoimmunology[J].Shandong Journal of Traditional Chinese Medicine,2022(3):343-347. |
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| Authors: | WANG Yangyang XU Yuan YUAN Gongming KANG Lijuan LYU Wei GUO Yongming |
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| Affiliation: | (Experimental Acupuncture and Moxibustion Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;College of Acu-Moxa and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China) |
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| Abstract: | The immune system and skeletal system share multiple signaling pathways and cytokines,and are connected through immune cells and bone tissue cells.The main content of osteoimmunology is to study the complex relationship between the both,which are also the underlying mechanism of bone destruction in rheumatoid arthritis.Acupuncture has good anti-inflammatory and analgesia effect,could regulate immunity and endocrine,and improve microcirculation.The mechanisms for the treatment of bone destruction in rheumatoid arthritis mainly through regulating osteocloclasts,regulating nuclear factorκ-B(NF-κB)receptor-activated protein ligand(RANKL)-RANK-osteoprotectin(OPG)pathway,regulating inflammatory factor.There are 35 papers cited in the references. |
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| Keywords: | osteoimmunology rheumatoid arthritis bone destruction acupuncture and moxibustion |
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