基于SCL-90量表评价养生健身方干预亚健康状态的临床研究

目的:基于SCL-90量表评价养生健身方干预亚健康状态的临床疗效。方法:观察组60例,其中中药观察组30例,采用养生健身方干预,模拟剂观察组30例,采用模拟剂干预;对照组60例,不进行任何药物干预。首先应用Logistic回归分析和判别分析获取特征性指标,再将获得的特征性指标用于临床疗效评价。结果:应用Logistic回归分析及判别分析,最终筛选出8项高区分度的指标,包括X17(发抖)、X29(感到孤独)、X37(感到人们对您不友好,不喜欢您)、X49(一阵阵发冷或发热)、X59(想到死亡的事)、X75(单独一人时神经很紧张)、X76(别人对您的成绩没有做出恰当的评价)、X83(害怕会在公共场合晕倒)。最后采用以上8种特征性指标对养生健身方进行疗效评价,发现与模拟剂比较,养生健身方可以显著改善亚健康状态人群的以上8项特征性指标,差异有统计学意义(P0.01);其总有效率分别为73.33%、66.67%、66.67%、70.00%、70.00%、80.00%、90.00%、76.67%,远优于模拟剂,差异有统计学意义(P0.01)。结论:养生健身方可以显著改善亚健康状态人群的以上8项特征性指标,为临床应用养生健身方论治亚健康状态提供了可靠的证据支持。

Clinical Study on Evaluation of Sub-health Intervened with Yangsheng Jianshen Formula Based on SCL-90

Objective:To evaluate the clinical efficacy of Yangsheng Jianshen Formula interventing in sub-health state based on Symptom Checklist-90(SCL-90). Methods:There were 60 cases in the experimental group,30 cas es in the traditional Chinese medicine(TCM) experimental group,with Yangsheng Jianshen Formula intervention,and 30 cases in the simulated agent test group,with the simulated agent intervention. There were 60 cases in the control group without any drug intervention. Logistic regression analysis and discriminant analysis were first applied to obtain characteristic indicators,and then the obtained characteristic indicators were used for clinical efficacy evaluation. Results:Based on the Logistic regression analysis and discriminant analysis,finally 8 indexes with high discrimination were selected,including X17(shivering),X29(lonely),X37(feel that people are unfriendly and don't like you),X49(a burst of chills or fever),X59(think of death),X75(feel very nervous when alone),X76(others have not properly evaluated your grades),X83(fear of fainting in public). Finally,the clinical efficacy of Yangsheng Jianshen Formula was evaluated by using the above 8 characteristic indexes. It was found that compared with the simulated agent,Yangsheng Jianshen Formula could significantly improve the above 8 characteristic indexes in people with sub-health status,with statistical significant difference(P<0.01),and the effectiveness rates were 73.33%,66.67%,66.67%,70%,70%,80%,90% and 76.67%,respectively,far better than those of the simulated agent,with statistical significant difference(P<0.01). Conclusion:Yangsheng Jianshen Formula can significantly improve the above 8 characteristic indexes of the sub-health status population and has significant curative effect,and this study provides a reliable evidence support for clinical application of Yangsheng Jianshen Formula to treat sub-health status.