射干麻黄汤联合沙丁胺醇对慢性阻塞性肺疾病患者肺功能、生活质量的影响

目的:探讨射干麻黄汤联合沙丁胺醇对慢性阻塞性肺疾病(COPD)患者肺功能、生活质量的影响。方法:选择COPD患者90例进行研究,以随机数字表法分为观察组48例和对照组42例。对照组给予沙丁胺醇治疗,观察组在对照组的基础上加用射干麻黄汤治疗。比较两组患者的临床疗效、第1秒用力呼气容积(FEV1)、最大呼气流量(PEF)、用力肺活量(FVC)、生活质量、中医症候积分、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(hs-CRP)水平变化情况及不良反应发生情况。结果:治疗后,两组总有效率分别为93.75%、76.19%(P<0.05); 治疗后,两组患者FEV1、PEF、FVC水平均得到显著改善,且观察组高于对照组(P<0.05); 治疗后,两组躯体、认知、情绪、角色、社会功能、总体健康评分水平均得到显著改善,且观察组高于对照组(P<0.05); 治疗后,两组中医症候积分、日间咳嗽积分、夜间咳嗽积分水平显著改善,且观察组低于对照组(P<0.05); 治疗后,两组患者血清IL-6、TNF-α、Hs-CRP水平均得到显著改善,且观察组低于对照组(P<0.05); 观察组不良反应总发生率为10.42%,对照组为16.67%,差异无统计学意义(P>0.05)。结论:射干麻黄汤联合沙丁胺醇治疗慢性阻塞性肺疾病效果显著,可有效改善患者肺功能、生活质量水平。

Effects of Shegan Mahuang decoction and albuterol on pulmonary function and quality of life in patients with COPD

Objective:To explore the effect of Shegan Mahuang decoction combined with salbutamol on pulmonary function and quality of life in patients with chronic obstructive pulmonary disease(COPD).Methods:90 patients with COPD were selected for the study,and divided into observation group(n=48)and control group(n=42)by random number table method.The control group was treated with salbutamol,and the observation group was treated with Shegan Mahuang decoction on the basis of the control group.The clinical effect,FEV1,PEF,FVC,QOL,TCM symptom score,IL-6,TNF-α,hs-CRP and adverse reactions were compared between the two groups.Results:After treatment,the total effective rates of the two groups were 93.75% and 76.19%(P<0.05); after treatment,the TCM symptom score,daytime cough score and night cough score of the two groups were significantly improved,and the level of the observation group was lower than that of the control group(P<0.05); after treatment,the serum IL-6,TNF - α and hs-CRP levels of the two groups were significantly improved,and the observation group was lower than the control group(P<0.05); the total incidence of adverse reactions in the observation group was 10.42%,and the control group was 16.67%.There was no significant difference(P>0.05).Conclusion:Shegan Mahuang decoction combined with salbutamol is effective in the treatment of COPD,which can effectively improve the pulmonary function and quality of life of patients.