| 左旋四氢巴马汀对大鼠局灶性脑缺血再灌注损伤后神经元凋亡和Caspase-3表达的影响 |
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| 引用本文： | 马小亚,谭婷,武冬梅,王美纳,梁维薇,王玉虎,王娜.左旋四氢巴马汀对大鼠局灶性脑缺血再灌注损伤后神经元凋亡和Caspase-3表达的影响[J].现代中药研究与实践,2011(4):33-36. |
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| 作者姓名： | 马小亚 谭婷 武冬梅 王美纳 梁维薇 王玉虎 王娜 |
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| 作者单位： | 西安交通大学医学院第二附属医院;西安市儿童医院; |
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| 基金项目： | 陕西省科学技术研究发展计划项目(2008k13-02(2)) |
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| 摘 要： | 目的 探讨左旋四氢巴马汀(L-THP)对大鼠局灶性脑缺血再灌注损伤神经元凋亡和半胱氨酸蛋白酶-3(Caspase-3)表达的影响.方法 实验大鼠随机分为4组,即假手术组、模型组、L-THP高、低剂量组(40、20 mg·kg-1·d-1).采用线栓法阻塞大脑中动脉建立大鼠局灶性脑缺血再灌注模型,于缺血1h再灌注6、24...
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| 关 键 词： | 左旋四氢巴马汀 脑缺血再灌注损伤 神经元凋亡 Caspase-3 |
Effects of L-tetrahydropalmatine on Neuronal Apoptosis and the Expression of Caspase-3 Protein after Focal Cerebral Ischemia Reperfusion Injure in Rats |
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| MA Xiao-ya,TAN Ting,WU Dong-mei,WANG Mei-na,LIANG Wei-wei,WANG Yu-hu,WANG Na.Effects of L-tetrahydropalmatine on Neuronal Apoptosis and the Expression of Caspase-3 Protein after Focal Cerebral Ischemia Reperfusion Injure in Rats[J].Research and Practice on Chinese Medicines,2011(4):33-36. |
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| Authors: | MA Xiao-ya TAN Ting WU Dong-mei WANG Mei-na LIANG Wei-wei WANG Yu-hu WANG Na |
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| Affiliation: | MA Xiao-ya1,TAN Ting1,WU Dong-mei2,WANG Mei-na1,LIANG Wei-wei1,WANG Yu-hu1,WANG Na1(1.The Second Affiliated Hospital,School of Medicine,Xi'an Jiaotong University,Xi'an 710004,China,2.Xi'an Children's Hospital,Xi'an 710003,China) |
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| Abstract: | Objective To explore the effects of l-tetrahydropalmatine(L-THP)on neuronal apoptosis and the expression of Caspase-3 in cerebral cortex after transient focal cerebral ischemia reperfusion injure in rats.Methods The experimental rats were randomly divided into 4 groups:sham group,model group,L-THP high dose group(40 mg kg-1 d-1) and L-THP low dose group(20 mg kg-1 d-1).Transient focal cerebral ischemia reperfusion model of rats' middle cerebral artery occlusion(MCAO) was induced by inserting a nylon filamen... |
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| Keywords: | L-tetrahydropalmatine cerebral ischemia reperfusion injury neuronal apoptosis Caspase-3 |
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