桃红四物汤对慢性心力衰竭血瘀证B型钠尿肽的影响

目的:观察桃红四物汤对慢性心力衰竭(chronic heart failure,CHF)血瘀证患者B型钠尿肽(NT-proBNP)水平的影响。方法:将139例CHF患者随机分为对照组67例和治疗组72例,对照组予以常规治疗,治疗组在对照组的基础上服用桃红四物汤,观察两组患者的临床疗效及治疗后NT-proBNP水平的变化情况。结果:治疗前证属气阴两虚、心血瘀阻型的患者NT-proBNP水平为(2 025.74±45.7)ng·L~(-1),证属气虚血瘀水停证型的患者NT-proBNP水平为(2174.23±108.1)ng·L~(-1),证属心肾阳虚、血瘀水停证的患者NT-proBNP水平为(2 347.26±62.6)ng·L~(-1),组间比较,有显著性差异(P0.05)。治疗组有效率87.5%,对照组有效率为82.1%,两组有效率比较,差异具有统计学意义(P0.05)。治疗后两组患者NT-proBNP水平均明显下降,与治疗前比较,差异具有显著性(P0.05),治疗后两组间比较,差异具有显著性(P0.05)。结论:桃红四物汤治疗血瘀型CHF临床疗效显著,NT-proBNP水平可作为CHF中医辨证分型的客观指标。

The Influence of Peach Kernel and Carthamus Four Substances Decoction on NT-pro-BNP of Syndrome of Blood Stasis due to Chronic Heart Failure

Objective:To observe the influence of Peach Kernel and Carthamus Four Substances Decoction on NT-pro-BNP of syndrome of blood stasis due to chronic heart failure (CHF).Methods:One hundred and thirty-nine patients with CHF were randomly divided into the control group and the treatment group,with 67 and 72 cases respectively in each group.The ones in the control group were given routine Western medicine treatment,while the ones in the treatment group were added Peach Kernel and Carthamus Four Substances Decoction for oral administratiou based on the treatment of the control group,then the clinical curative effects and changes of NT-pro-BNP levels of the two groups were observed.Results:Before the treatment,the level of NT-pro-BNP of patients with syndrome of deficiency of both qi and yin of cariac blood stasis type was(2025.74±45.7) ng· L-1,which that of qi deficiency,blood stasis and water retention syndrome was (2174.23±108.1) ng·L-1,and that of yang deficiency of the heart and kidney and blood stasis and water retention syndrome was (2347.26±62.6) ng·L-1,and the differences between groups had siguificance (P＜0.05).The effective rate of the treatment group was 87.5％,while that of the control group was 82.1％;And the difference between them had statistical significance (P＜0.05).After the treatment,the difference between groups had statistical significance (P＜0.05).Conclusion:Peach Kernel and Carthamus Four Substances Decoction has a remarkable clinical curative effect on CHF of blood stasis type,and the level of NT-pro-BNP can be regarded as one objective index of CHF TCM differentiation classification.