| 正交试验优化芹菜素锌络合反应合成条件的研究 |
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| 引用本文： | 余陈欢,张蓓,李效贤,史长城,熊耀康.正交试验优化芹菜素锌络合反应合成条件的研究[J].亚太传统医药,2009,5(7):13-15. |
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| 作者姓名： | 余陈欢 张蓓 李效贤 史长城 熊耀康 |
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| 作者单位： | 浙江中医药大学,浙江,杭州,310053 |
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| 摘 要： | 目的:优化芹菜素锌配位化合物的合成条件。方法:在单因素实验的基础上,采用正交试验对芹菜素与醋酸锌络合反应的工艺参数进行优化。结果:反应温度和体系的pH值对芹菜素锌配合物的产率具有显著影响,通过方差分析得到优化的络合反应条件为:在体系pH值为9的条件下,50℃络合反应5h,产率为77.51%。结论:该工艺稳定可行,芹菜素锌配合物产率较高。
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| 关 键 词： | 芹菜素 芹菜素锌配合物 正交试验 工艺优化 |
Study on Optimization of Complexing Condition between Apigenin and Zinc by Orthogonal Design |
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| Yu Chenhuan,Zhang Bei,Li Xiaoxian,Shi Changcheng,Xiong Yaokang.Study on Optimization of Complexing Condition between Apigenin and Zinc by Orthogonal Design[J].Asia-Pacific Traditional Medicine,2009,5(7):13-15. |
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| Authors: | Yu Chenhuan Zhang Bei Li Xiaoxian Shi Changcheng Xiong Yaokang |
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| Affiliation: | (Zhejiang Chinese Medical University, Hangzhou 310053, China) |
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| Abstract: | Objective： To optimize the synthesis of apigenin-Zn complex Methods： Based on the results of single factor, the synthesis process was employed combining with orthogonal design to optimize the complexing conditions for making apigenin-zinc complex Results： A mathematical model was then developed to show the significant effect of temperature and pH on the yield of apigenin-zinc complex The analysis was used to estimate that a maximal yield of apigenin-zine complex could be obtained when temperature, time and pH was 50℃, 5 hours and prig. The experiment result was 77. 51%. Conclusion：The extraction process is stable and feasible |
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| Keywords: | Synthesis Apigenin Apigenin-zinc complex Orthogonal design |
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