| 壮药鸡尾木的化学成分及其细胞毒活性 |
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| 引用本文： | 宁德生,闫晓旭,黄思思,程玲,李娟,潘争红.壮药鸡尾木的化学成分及其细胞毒活性[J].中国中药杂志,2015,40(4):686-690. |
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| 作者姓名： | 宁德生 闫晓旭 黄思思 程玲 李娟 潘争红 |
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| 作者单位： | 广西植物功能物质研究与利用重点实验室, 广西植物研究所, 广西 桂林 541006,云南师范大学, 云南 昆明 650500,广西植物功能物质研究与利用重点实验室, 广西植物研究所, 广西 桂林 541006,云南师范大学, 云南 昆明 650500,广西植物功能物质研究与利用重点实验室, 广西植物研究所, 广西 桂林 541006,广西植物功能物质研究与利用重点实验室, 广西植物研究所, 广西 桂林 541006 |
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| 基金项目： | 国家自然科学基金项目(21102023);广西植物功能物质研究与利用重点实验室主任基金项目(ZRJJ2013-8) |
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| 摘 要： | 采用硅胶、MCI、ODS柱色谱等色谱技术,从鸡尾木95%乙醇提取物中分离得到14个化合物。经波谱数据分析并结合文献对照,分别鉴定为槲皮素(1)、山柰酚(2)、(+)-儿茶素(3)、秦皮苷(4)、原儿茶酸(5)、没食子酸(6)、没食子酸甲酯(7)、没食子酸乙酯(8)、罗布麻酚A(9)、巴卡亭(10)、酵母甾醇(11)、鞣花酸(12)、3,3’,4’-三甲氧基鞣花酸(13)、N-benzoylL-phenylalaninyl-N-benzoyl-L-phenylalaninate(14)。除化合物6以外,其余化合物均为首次从该植物中分离得到,化合物1,2,6具有一定的抑制肿瘤细胞增殖作用。
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| 关 键 词： | 鸡尾木 壮药 化学成分 结构鉴定 抗肿瘤 |
| 收稿时间： | 2014/12/8 0:00:00 |
Studies on chemical constituents of Zhuang medicine Excoecaria venenata and their cytotoxic activity |
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| NING De-sheng,YAN Xiao-xu,HUANG Si-si,CHENG Ling,LI Juan and PAN Zheng-hong.Studies on chemical constituents of Zhuang medicine Excoecaria venenata and their cytotoxic activity[J].China Journal of Chinese Materia Medica,2015,40(4):686-690. |
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| Authors: | NING De-sheng YAN Xiao-xu HUANG Si-si CHENG Ling LI Juan and PAN Zheng-hong |
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| Affiliation: | Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, guangxi Institute of Botany, Guilin 541006, China,Yunnan Normal University, Kunming 650500, China,Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, guangxi Institute of Botany, Guilin 541006, China,Yunnan Normal University, Kunming 650500, China,Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, guangxi Institute of Botany, Guilin 541006, China and Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, guangxi Institute of Botany, Guilin 541006, China |
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| Abstract: | Fourteen compounds were isolated from 95% ethanol extract by silica gel, MCI, and ODS column chromatography. These compounds were respectively identified as quercetin(1), kaempferol(2),(+)-catechin(3), fraxin(4), protocatechuic acid(5), gallic acid(6), methyl gallate(7), ethyl gallate(8), apocynol A(9), baccatin(10), cerevisterol(11), ellagic acid(12), 3,3',4'-tri-O-methylellagic acid(13) and N-benzoyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate(14) by analyzing their spectral data and comparing with the previously reported literatures. Except for gallic acid(6), all other compounds were isolated from this plant for the first time. Compounds 1, 2 and 6 showed moderate anti-proliferation activities on tumor cells. |
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| Keywords: | Excoecaria venenata Zhuang medicine chemical constituents structural identification antitumor |
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