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朱砂溶出的体外研究
引用本文:曾克武,王旗,杨晓达,王夔.朱砂溶出的体外研究[J].中国中药杂志,2007,32(3):231-234.
作者姓名:曾克武  王旗  杨晓达  王夔
作者单位:1. 北京大学,药学院,化学生物学系,北京,100083
2. 北京大学,公共卫生学院,毒理学系,北京,100083
基金项目:国家科技攻关项目;国家自然科学基金
摘    要:目的:研究胃肠道中存在的各种化学因素(酸度,蛋白质,氨基酸,离子强度,Na2S)对朱砂溶出的影响。方法:分别使用紫外可见分光光度仪、纳米粒度仪、质谱仪对朱砂在不同化学体系溶出液中汞的浓度、溶出液的粒度分布以及溶出物的组成进行分析。结果:朱砂主要不以纳米颗粒形式溶出,含巯基的氨基酸对朱砂的促溶作用有限,而Na2S对朱砂中汞溶出量的影响显著高于其他,pH对朱砂中汞的溶出量也有较大的影响。结论:推测朱砂在胃肠道中的溶出物可能主要为汞的各种含硫配合物。

关 键 词:朱砂  硫化汞  溶出  多硫化汞
文章编号:1001-5302(2007)03-0231-04
收稿时间:2006-10-23
修稿时间:2006-10-23

Investigation on dissolution of cinnabar In vitro
ZENG Ke-wu;WANG Qi;YANG Xiao-da;WANG Kui.Investigation on dissolution of cinnabar In vitro [J].China Journal of Chinese Materia Medica,2007,32(3):231-234.
Authors:ZENG Ke-wu;WANG Qi;YANG Xiao-da;WANG Kui
Affiliation:1. Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100083, China; 2. Department of Toxicology, Peking University School of Public Health, Beijing 100083, China
Abstract:Objective: To study effects of different chemical factors in gastrointestinal tract,i.e.pH,protein,amino acid,ionic strength,Na2S,on the dissolution of cinnabar.Method: The content of total mercury in various dissolution of cinnabar were analyzed by UV/VIS Spectrophotometer.The particle distributions in dissolution of cinnabar were measured by Laser Particle Size Analyzer.The constituents of dissoluble substance of cinnabar in presence of Na2S were determined using ESI-MS.Result: The solubility of cinnabar could be increased significantly in the presence of Na2S/S0,and strong acidic pH,respectively.While the influence of thiol amino acid on promoting dissolution remains relatively low.Cinnabar didn't dissolve mainly in the form of nanoparticle.Conclusion: We postulated that cinnabar could be dissolved in various forms of mercury complexes containing sulphur.
Keywords:cinnabar  mercury sulphide  dissolution  mercury polysulfide
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