| 瓜馥木枝叶中生物碱类化学成分研究 |
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| 引用本文： | 钟圣海,付艳辉,周学明,宋小平,陈光英.瓜馥木枝叶中生物碱类化学成分研究[J].中国中药杂志,2016,41(15):2838-2842. |
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| 作者姓名： | 钟圣海 付艳辉 周学明 宋小平 陈光英 |
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| 作者单位： | 海南师范大学 热带药用植物化学教育部重点实验室, 海南 海口 571158,海南师范大学 热带药用植物化学教育部重点实验室, 海南 海口 571158,海南师范大学 热带药用植物化学教育部重点实验室, 海南 海口 571158,海南师范大学 热带药用植物化学教育部重点实验室, 海南 海口 571158,海南师范大学 热带药用植物化学教育部重点实验室, 海南 海口 571158 |
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| 基金项目： | 973计划前期研究专项（2014CB560714） |
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| 摘 要： | 采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备HPLC等色谱方法对番荔枝科瓜馥木属植物瓜馥木Fissistigma oldhamii中生物碱类化学成分进行了系统的分离与纯化,运用理化分析及NMR、MS等现代波谱学方法对其结构进行鉴定。从瓜馥木枝叶的总生物碱提取物中共分离得到14个生物碱类化合物,分别鉴定为:去甲头花千金藤二酮(1)、巴婆碱(2)、毛叶含笑碱(3)、六驳碱(4)、异紫堇定碱(5)、番荔枝叶碱(6)、甲氧番荔枝碱(7)、N-methylbuxifoline(8)、aristolactam AIIIa(9)、piperumbellactam A(10)、goniopedaline(11)、aristolactam BIII(12)、鹅掌揪碱(13)和salutaridine(14)。其中化合物3~5,8,10,11和14为首次从瓜馥木属植物中分离得到。
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| 关 键 词： | 番荔枝科 瓜馥木属 瓜馥木 生物碱 |
| 收稿时间： | 5/8/2016 12:00:00 AM |
Studies on alkaloids from Fissistigma oldhamii |
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| ZHONG Sheng-hai,FU Yan-hui,ZHOU Xue-ming,SONG Xiao-ping and CHEN Guang-ying.Studies on alkaloids from Fissistigma oldhamii[J].China Journal of Chinese Materia Medica,2016,41(15):2838-2842. |
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| Authors: | ZHONG Sheng-hai FU Yan-hui ZHOU Xue-ming SONG Xiao-ping and CHEN Guang-ying |
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| Affiliation: | Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China,Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China,Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China,Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China and Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China |
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| Abstract: | 14 alkaloids were obtained from stems and leaves of Fissistigma oldhamii, by silica gel, ODS, Sephadex LH-20 column chromatographies, and semi-preparative HPLC. Using physicochemical and spectral methods, the isolated alkaloids were identified as norcepharadione B(1), asimilobine(2), lanuginosine(3), laurotanine(4), isocorydine(5), anolobine(6), xylopine(7), N-methylbuxifoline(8), aristolactam AIIIa(9), piperumbellactam A(10), goniopedaline(11), aristololactam BIII(12), liriodenine(13), and salutaridine(14), respectively. Compounds 3-5, 8, 10, 11 and 14 were isolated from the genus Fissistigma for the first time. |
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| Keywords: | Annonaceae Fissistigma Fissistigma oldhamii alkaloids |
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