| 大八角根化学成分研究 |
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| 引用本文： | 牛长山,王亚丹,屈晶,庾石山,李勇,刘云宝,马双刚,吕海宁,陈霞,徐嵩.大八角根化学成分研究[J].中国中药杂志,2014,39(14):2689-2692. |
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| 作者姓名： | 牛长山 王亚丹 屈晶 庾石山 李勇 刘云宝 马双刚 吕海宁 陈霞 徐嵩 |
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| 作者单位： | 中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050;中国医学科学院 北京协和医学院 药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050 |
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| 基金项目： | 国家自然科学基金项目（21132009） |
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| 摘 要： | 采用硅胶、Sephadex LH-20、ODS及制备型HPLC等多种色谱技术，从大八角根中分离得到10个化合物，根据理化性质及波谱数据（MS，1H，13C-NMR）分析分别鉴定为cycloparviflorolide（1），cycloparvifloralone（2），tashironin（3），tashironin A（4），anislactone A（5），anislactone B（6），pseudomajucin（7），syringaldehyde（8），methyl-4-hydroxy-3，5-dimethoxybenzoate（9）和（E）-3-methoxy-4，5- methylenedioxycinnamic alchol（10）。其中化合物 1~4，8~10 为首次从该植物中分离得到。在1.0×10-5 mol·L-1下，在LPS刺激小鼠小胶质细胞释放NO抑制模型上，化合物 5，6 抑制率分别为75.31%，53.7%。
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| 关 键 词： | 大八角 化学成分 倍半萜 |
| 收稿时间： | 2014/4/18 0:00:00 |
Chemical constituents from roots of Illicium majus |
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| NIU Chang-shan,WANG Ya-dan,QU Jing,YU Shi-shan,LI Yong,LIU Yun-bao,MA Shuang-gang,LV Hai-ning,CHEN Xia and XU Song.Chemical constituents from roots of Illicium majus[J].China Journal of Chinese Materia Medica,2014,39(14):2689-2692. |
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| Authors: | NIU Chang-shan WANG Ya-dan QU Jing YU Shi-shan LI Yong LIU Yun-bao MA Shuang-gang LV Hai-ning CHEN Xia and XU Song |
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| Affiliation: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Ten compounds, including seven sesquiterpenes, two phenols and one phenylpropanoid, were isolated from the roots of Illicium majus by means of silica gel, ODS, Sephadex LH-20, and preparative HPLC. On analysis of MS and NMR spectroscopic data, their structures were established as cycloparviflorolide(1), cycloparvifloralone(2),tashironin(3), tashironin A(4), anislactone A(5), anislactone B(6), pseudomajucin(7), syringaldehyde(8), methyl-4-hydroxy-3,5-dimethoxybenzoate(9), and(E)-3-methoxy-4,5-methylenedioxycinnamic alchol(10), respectively. Compounds 1-4 and 8-10 were first isolated from this plant. In the in vitro assays, at a concentration of 1.0×10-5 mol·L-1, compounds 5 and 6 were active against LPS induced NO production in microglia with a inhibition rate of 75.31% and 53.7%, respectively. |
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| Keywords: | Illicium majus chemical constituents sesquiterpene |
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