| 翠绿针毛蕨中特殊B环结构的黄酮及其抑制 肿瘤细胞增殖作用的研究 |
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| 引用本文： | 魏安华,吴光华,熊朝梅,周道年,蔡亚玲,阮金兰.翠绿针毛蕨中特殊B环结构的黄酮及其抑制 肿瘤细胞增殖作用的研究[J].中国中药杂志,2011,36(5):582-584. |
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| 作者姓名： | 魏安华 吴光华 熊朝梅 周道年 蔡亚玲 阮金兰 |
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| 作者单位： | 1. 华中科技大学同济药学院,湖北,武汉,430030;华中科技大学创新研究院,湖北,武汉,430030
2. 华中科技大学同济药学院,湖北,武汉,430030 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金(20090142110021) |
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| 摘 要： | 目的:研究翠绿针毛蕨Macrothelypteris viridifyons的化学成分及其抑制肿瘤细胞增殖作用.方法:利用硅胶、C18反相硅胶、Sephadex LH-20凝胶等色谱技术对其提取物进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定,以MTT法测试各化合物对MOLT-4,Hep G2,A-549,MCF-7,HT-29,PC-3肿瘤细胞增殖的抑制作用.结果:分离得到5个具有特殊B环结构的黄酮类化合物,分别鉴定为:原芹菜素(1),4-羟基-原芹菜素(2),4'-羟基-原芹菜素4'-O-β-D-葡萄糖苷(3),5,7-二羟基-2-(1,2-异丙二氧基-4-酮-环己-5-烯)-色原酮(4),5,7-二羟基-2-(1-羟基-2,6-二甲氧基-环己-4-酮)-色原酮(5).结论:所有化合物均首次从翠绿针毛蕨中分离得到,化合物1,4和5对6种人肿瘤细胞增殖有明显的抑制作用,且呈现出良好的剂量依赖性.
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| 关 键 词： | 翠绿针毛蕨 黄酮 抗增殖作用 |
| 收稿时间： | 8/3/2010 12:00:00 AM |
Flavonoids with special B-ring from Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell |
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| WEI Anhu,WU Guanghu,XIONG Chaomei,ZHOU Daonian,CAI Yaling and RUAN Jinlan.Flavonoids with special B-ring from Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell[J].China Journal of Chinese Materia Medica,2011,36(5):582-584. |
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| Authors: | WEI Anhu WU Guanghu XIONG Chaomei ZHOU Daonian CAI Yaling and RUAN Jinlan |
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| Affiliation: | College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;Institute of Innovation, Huazhong University of Science and Technology, Wuhan 430030,China;College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;College of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan 430030,China;Institute of Innovation, Huazhong University of Science and Technology, Wuhan 430030,China |
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| Abstract: | Objective:To study the chemical constituents of Macrothelypteris viridifrons and their anti-proliferative effects on tumor cell.Method:The compounds were isolated by column chromatography with silica gel,C18 reverse-phase silica gel,sephadex LH-20,and their structures were elucidated on the basis of physiochemical propertities and spectral analysis.The antitumor activities of all compounds were tested with MOLT-4,Hep G2,A-549,MCF-7,HT-29,PC-3 tumor cell lines.Result:Five compounds were isolated and identifi... |
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| Keywords: | Macrothelypteris viridifrons flavonoid anti-proliferative effect |
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