| 豆豉姜的生物碱类成分研究 |
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| 引用本文： | 张水英,郭强,曹愿,张媛,高小力,屠鹏飞,柴兴云.豆豉姜的生物碱类成分研究[J].中国中药杂志,2014,39(20):3964-3968. |
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| 作者姓名： | 张水英 郭强 曹愿 张媛 高小力 屠鹏飞 柴兴云 |
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| 作者单位： | 北京中医药大学 中药现代研究中心, 北京 100029;北京中医药大学 中药学院, 北京 100102;北京中医药大学 中药现代研究中心, 北京 100029;北京中医药大学 中药学院, 北京 100102;北京中医药大学 中药现代研究中心, 北京 100029;北京中医药大学 中药学院, 北京 100102;北京中医药大学 中药学院, 北京 100102;北京中医药大学 中药现代研究中心, 北京 100029;北京中医药大学 中药现代研究中心, 北京 100029;北京中医药大学 中药现代研究中心, 北京 100029 |
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| 基金项目： | 国家药典委员会2015版《中国药典》课题——豆豉姜的质量标准增订 |
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| 摘 要： | 作为2015版《中国药典》项目——豆豉姜的质量标准增订工作的一部分,本研究对豆豉姜进行了化学成分研究。利用硅胶、Sephadex LH-20、ODS等色谱技术分离得到了7个异喹啉生物碱,并通过MS,1D和2D NMR波谱数据分析及与文献相比对等方法,分别鉴定为(+)-去甲波尔定(1)、(+)-波尔定(2)、(+)-瑞枯灵(3)、(+)-六驳碱(4)、(+)-异波尔定(5)、(+)-N-甲基六驳碱(6)、小檗碱(7),其中化合物7为首次从本属中分离得到。利用BV-2和RAW264.7细胞炎症模型评价其体外抗炎作用,化合物1,2,5和7显示中度至微弱的活性。
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| 关 键 词： | 豆豉姜 山鸡椒 生物碱 抗炎活性 |
| 收稿时间： | 2014/5/22 0:00:00 |
Alkaloids from roots and stems of Litsea cubeba |
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| ZHANG Shui-ying,GUO Qiang,CAO Yuan,ZHANG Yuan,GAO Xiao-li,TU Peng-fei and CHAI Xing-yun.Alkaloids from roots and stems of Litsea cubeba[J].China Journal of Chinese Materia Medica,2014,39(20):3964-3968. |
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| Authors: | ZHANG Shui-ying GUO Qiang CAO Yuan ZHANG Yuan GAO Xiao-li TU Peng-fei and CHAI Xing-yun |
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| Affiliation: | Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | A phytochemical investigation on the roots and stems of Litsea cubeba led to the isolation of seven isoquinolone alkaloids. By spectroscopic analysis and comparison of their 1H and 13C-NMR data with those in literatures, these alkaloids were identified as (+)-norboldine (1), (+)-boldine (2), (+)- reticuline(3), (+)-laurotetanine (4), (+)-isoboldine (5), (+)-N-methyllaurotetanine (6), and berberine (7), respectively. Among them, 7 was isolated from the genus for the first time. The evaluation of these compounds showed weak anti-inflammatory activity against NO production in RAW 267.4 and BV-2 cells. |
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| Keywords: | Lauraceae Litsea cubeba alkaloids anti-inflammatory activity |
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