| 信宜润楠中的黄酮类成分 |
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| 引用本文： | 程伟,许文东,樊晓娜,石建功.信宜润楠中的黄酮类成分[J].中国中药杂志,2014,39(19):3794-3797. |
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| 作者姓名： | 程伟 许文东 樊晓娜 石建功 |
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| 作者单位： | 天然药物活性物质与功能国家重点实验室, 中国医学科学院 北京协和医学院 药物研究所, 北京 100050;天然药物活性物质与功能国家重点实验室, 中国医学科学院 北京协和医学院 药物研究所, 北京 100050;天然药物活性物质与功能国家重点实验室, 中国医学科学院 北京协和医学院 药物研究所, 北京 100050;天然药物活性物质与功能国家重点实验室, 中国医学科学院 北京协和医学院 药物研究所, 北京 100050 |
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| 基金项目： | 国家自然科学基金项目（30825044）；国家"重大新药创制"科技重大专项（2011ZX09307-002-01） |
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| 摘 要： | 通过大孔吸附树脂、正相硅胶、Sephadex LH-20柱色谱,以及反相闪式柱色谱和HPLC等多种分离方法相结合,从信宜润楠95%乙醇提物中首次分离得到12个黄酮类化合物;借助红外、质谱和核磁共振等波谱学分析方法分别鉴定为(+)-儿茶素(1)、(-)-表儿茶素(2)、3’-甲氧基-(+)-儿茶素(3)、3’-甲氧基-(-)-表儿茶素(4)、3,5,7,2’,5’-五羟基黄烷(5)、(-)-柚皮素(6)、(-)-圣草酚(7)、(-)-甘草素(8)、(2R,3R)-(+)-二氢山柰酚(9)、(2R,3S)-(-)-二氢山柰酚(10)、(2R,3R)-(+)-紫杉叶素(11)和槲皮素(12);其中,化合物1~10为首次从润楠属植物中分离得到。
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| 关 键 词： | 润楠属 信宜润楠 黄酮类 分离和结构鉴定 |
| 收稿时间： | 2014/6/26 0:00:00 |
Flavonoids from root of Machilus wangchiana |
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| CHENG Wei,XU Wen-dong,FAN Xiao-na and SHI Jian-gong.Flavonoids from root of Machilus wangchiana[J].China Journal of Chinese Materia Medica,2014,39(19):3794-3797. |
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| Authors: | CHENG Wei XU Wen-dong FAN Xiao-na and SHI Jian-gong |
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| Affiliation: | State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Twelve flavonoids were isolated from an ethanol extract of Machilus wangchiana by a combination of various chromatographic techniques including column chromatography over silica gel and Sephadex LH-20 and reversed-phase flash chromatography and HPLC. Their structures were identified by spectroscopic data analysis (IR, MS, and NMR) as (+)-catechin (1), (-)-epicatechin (2), 3'-O-methyl-(+)-catechin (3), 3'-O-methyl-(-)-epicatechin (4), 3,5,7,2',5'-pentahydroxy flavan (5), (-)-naringenin (6), (-)-eriodictyol (7), (-)-liquiritigenin (8), (2R,3R)-(+)-dihydrokaempferol (9), (2R,3S)-(-)-dihydrokaempferol (10), (2R,3R)-(+)-taxifolin (11), and quercetin (12). Compounds 1-10 are isolated from the genus Machilus for the first time. |
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| Keywords: | Machilus Machilus wangchiana flavonoids isolation and structure identification |
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