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| 中药注射剂致敏成分群筛查方法研究的现状与免疫综合法 | |
| 引用本文： | 贺福元,邓凯文,曾姣丽,戴儒文,夏赞韶,刘文龙,石继连.中药注射剂致敏成分群筛查方法研究的现状与免疫综合法[J].中国中药杂志,2012,37(19):2836-2841. |
| 作者姓名： | 贺福元 邓凯文 曾姣丽 戴儒文 夏赞韶 刘文龙 石继连 |
| 作者单位： | 1. 湖南中医药大学 药学院,湖南 长沙 410208;中药药性与药效国家中医药管理局重点实验室,湖南 长沙 410208 2. 湖南中医药大学 现代中药制剂制备与评价实验室,湖南 长沙,410208 3. 中药药性与药效国家中医药管理局重点实验室,湖南 长沙,410208 |
| 基金项目： | 国家自然科学基金项目(81073142,81173558);湖南省自然基金重点项目(11JJ2055);湖南省教育厅重点项目(09A068) |
| 摘 要： | 中药注射剂在我国已有60多年的发展及应用历程,近些年来不良反应的报道层出不穷.筛查中药注射剂的致敏成分群(致敏原群)的研究为世人关注,已成为国际性难题.该文先根据其产生免疫毒性的机制,分析中药注射剂致敏原筛查技术研究的现状,然后提出采用免疫底、盖芯片及免疫指纹图谱相结合的免疫综合分析筛查中药注射剂致敏成分群,旨在为中药注射剂的研制与临床使用构筑安全性评价屏障. |
| 关 键 词： | 中药注射剂 免疫毒性 致敏原 类致敏原 免疫芯片 免疫指纹图 免疫综合法 |
| 收稿时间： | 3/6/2012 12:00:00 AM |
Current state of studies on screening method for sensitinogens in injections for traditional Chinese medicine and synthetic immunity method |
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| HE Fu-yuan,DENG Kai-wen,ZENG Jiao-li,DAI Ru-wen,XIA Zan-shao,LIU Weng-long and SHI Ji-lian.Current state of studies on screening method for sensitinogens in injections for traditional Chinese medicine and synthetic immunity method[J].China Journal of Chinese Materia Medica,2012,37(19):2836-2841. | |
| Authors: | HE Fu-yuan DENG Kai-wen ZENG Jiao-li DAI Ru-wen XIA Zan-shao LIU Weng-long and SHI Ji-lian |
| Affiliation: | Department of Pharmaceutics, Hu'nan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China;Modern Pharmaceutical Preparation Technology and Evaluation Laboratory for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China;Department of Pharmaceutics, Hu'nan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China;Department of Pharmaceutics, Hu'nan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China;Department of Pharmaceutics, Hu'nan University of Chinese Medicine, Changsha 410208, China;Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica, State Administration of Chinese Medicine, Changsha 410208, China |
| Abstract: | Injections for traditional Chinese medicine have over 60 years of history of development and application. In recent years,however,their adverse reactions have been reported one after another. Consequently,studies on screening sensitinogens (sensibiligens) from injections for traditional Chinese medicine have drawn people's attention and become a tough problem all over the world. This essay analyzes the current state of studies on screening techniques of sensitinogens in injections for traditional Chinese medicine according their mechanism of immunotoxicity,and then proposes to adopt the synthetic immunoassay combining immunity bottle chip,immunity cover chip and immunity chromatographic fingerprint to screen sensitinogens from injections for traditional Chinese medicine,in order to build a safety evaluation barrier for development and clinical application of injections for traditional Chinese medicine. |
| Keywords: | injections for traditional Chinese medicine immunotoxicity sensitinogen similar sensitinogen immunity chip immunity chromatographic fingerprint synthetic immunity method |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
