中药免疫2号方对艾滋病患者免疫重建的研究

目的:通过中药免疫2号方联合HAART干预艾滋病HAART后免疫重建不全患者,观察中药复方对免疫重建有效率、CD4细胞及亚群的影响,评价免疫重建效果.方法:在全国4个中心进行多中心随机盲法研究,选择HAART治疗1年以上,免疫重建不全的患者264例,随机分为治疗组(131例)和对照组(133例),分别采用免疫2号方(每天2次,每次1包,每包6.2g)联合HAART治疗(AZT 300 mg +3TC 150 mg+ NVP 200 mg,bid)和安慰剂(每天2次,每次1包,每包6.2g)联合HAART治疗(AZT 300 mg+ 3TC 150 mg+ NVP 200 mg,bid).观察周期6个月,观察2组患者治疗前后CD4,CD8,CD45RA,CD45RO细胞绝对计数,CD4CD28,CD8CD28,CD8CD38,HLA-DR,CD4CD25的相对计数,评价其对免疫功能的影响和免疫重建有效率.结果:中药干预6个月后,治疗组免疫重建有效率达34.48％,对照组有效率21.37％,且组间比较差异有统计学意义(P =0.021 7).CD4,CD45RA,CD45RO细胞绝对计数治疗组与对照组比较均能显著提高(P＜0.05);CD8,CD3,CD4CD28绝对计数比较组间无显著差异;CD8CD28相对计数治疗组比对照组显著提高(P＜0.05);CD4CD28,CD8CD38,CD8DR,CD4CD25相对计数组间比较无显著性差异.结论:免疫2号方干预HAART后免疫重建不全艾滋病患者治疗6月后,能够提高患者CD4,CD45RA,CD45RO细胞绝对计数,提高免疫重建有效率,促进免疫重建.

Effect of Immune 2 with highly active antiretroviral treatment on immune function of HIV/AIDS patients with poor immune reconstitution

Objective: To observe the effection of immune reconstitution efficiency and the immune function on Immune 2 with HAART to HIV/AIDS patients which poor immune reconstitution after HAART. Method: Two hundred and sixty four patients failure to immune reconstitution after HAART were randomly divided into treatment group (131 cases) and control group (133 cases), respectively, using Immune 2 plus HAART and placebo combined with HAART for 6 months. the CD4, CD8, CD45RA, CD45RO, CD4CD28, CD8CD28, CD8CD38, HLA-DR and CD4CD25 were observed in order to evaluate the immune reconstitution efficiency. Result: After the intervention for 6 months, the effective rate of treatment group (34.48%) was significantly superior to the control group (21.37%) (P=0.021 7). Treated group could significantly increased the CD4, CD45RA, CD45RO cell counts compared with control group (P<0.05); CD8, CD3, CD4CD28 absolute count comparison between the two groups had no significant difference; CD8CD28 relative counting the treatment group group significantly increased (P<0.05) compared to the control; CD4CD28, CD8CD38, CD8DR, CD4CD25 relative counting groups showed no significant difference. Conclusion: Immune 2 can effectively improve the immune reconstitution efficiency, CD4 counts, CD45RA counts and CD45RO counts of patients after HAART, therefore promoting immune reconstitution.