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| 雷公藤多苷对糖尿病肾病模型肾小球损伤的影响 | |
| 引用本文： | 张慧兰,孙伟,万毅刚,车晓艳,贺芳,濮红萍,窦晨辉.雷公藤多苷对糖尿病肾病模型肾小球损伤的影响[J].中国中药杂志,2010,35(11):1460-1465. |
| 作者姓名： | 张慧兰 孙伟 万毅刚 车晓艳 贺芳 濮红萍 窦晨辉 |
| 作者单位： | 1. 南京中医药大学,江苏南京,210029;马来西亚东方中医药进修学院,吉隆坡,58200 2. 江苏省中医院,肾内科,江苏南京,210029 3. 南京大学,医学院,附属鼓楼医院,中医科,江苏南京,210008 4. 南京中医药大学,江苏南京,210029 |
| 基金项目： | 南京市科技发展计划项目(200905006) |
| 摘 要： | 目的:观察雷公藤多苷(multi-glycoside of Tripterygium wilfordii,GTW)对糖尿病肾病模型肾小球损伤的改善效果.方法:运用链脲佐菌素(streptozotocin,STZ)建立糖尿病肾病模型,以GTW干预,并设立正常、安慰剂以及贝那普利对照组.比较体重、尿微量白蛋白(urine albumin,UAlb)、血糖(blood glucose,BG)、血清肌酐(serum creatinine,Scr)、血清尿素氮(blood urea nitrogen,BUN)以及肾小球形态(细胞总数、细胞外基质)的变化,并检测肾小球中α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA),Ⅰ型胶原的表达水平.结果:GTW和贝那普利都可以减少模型鼠UAlb;对于模型鼠肾小球硬化性损伤,如系膜细胞增生,α-SMA和Ⅰ型胶原异常表达等,GTW的作用强于贝那普利,肾小球总细胞数GTW组(54.44±2.41),贝那普利组(67.83±4.41),P＜0.05;α-平滑肌肌动蛋白积分GTW组(1.98±0.52),贝那普利组(2.27±0.46),P＜0.05;Ⅰ型胶原积分GTW组(2.11±0.37),贝那普利组(2.88±0.58),P＜0.05.结论:GTW改善DN肾小球损伤的效果包括减少蛋白尿和改善肾小球硬化. |
| 关 键 词： | 雷公藤多苷 糖尿病肾病 肾小球硬化 |
| 收稿时间： | 2009/10/22 0:00:00 |
Preventive effects of multi-glycoside of Tripterygium wilfordii on glomerular lesions in experimental diabetic nephropathy |
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| ZHANG Huilan,SUN Wei,WAN Yigang,CHE Xiaoyan,HE Fang,PU Hongping and DOU Chenhui.Preventive effects of multi-glycoside of Tripterygium wilfordii on glomerular lesions in experimental diabetic nephropathy[J].China Journal of Chinese Materia Medica,2010,35(11):1460-1465. | |
| Authors: | ZHANG Huilan SUN Wei WAN Yigang CHE Xiaoyan HE Fang PU Hongping and DOU Chenhui |
| Affiliation: | Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China;Oriental Academy of Chinese Medicine, Selangor 58200, Malaysia;Department of Nephrology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China;Department of Traditional Chinese Medicine, Affiliated Drum Tower Hospital of Nanjing UniversityMedical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Affiliated Drum Tower Hospital of Nanjing UniversityMedical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Affiliated Drum Tower Hospital of Nanjing UniversityMedical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Affiliated Drum Tower Hospital of Nanjing UniversityMedical School, Nanjing 210008, China;Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China |
| Abstract: | |
| Keywords: | multi-glycoside of Tripterygium wilfordii(GTW) diabetic nephropathy(DN) glomerulosclerosis |
| 本文献已被 万方数据 等数据库收录！ | |
