| 柴郁汤的抗炎作用研究 |
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| 引用本文： | 朱爱江,方步武,吴咸中,田在善,张永进,郭世铎,李东华.柴郁汤的抗炎作用研究[J].中药药理与临床,2011(3):98-101. |
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| 作者姓名： | 朱爱江 方步武 吴咸中 田在善 张永进 郭世铎 李东华 |
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| 作者单位： | 天津第三中心医院;天津医科大学药理教研室;天津市中西医结合急腹症研究所; |
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| 基金项目： | 天津市科技攻关计划重大科技项目(05YFGDSF02600):分项目(按治则归类进行新药开发与作用机理研究) |
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| 摘 要： | 目的:探讨柴郁汤的抗炎作用及其机理。方法:采用角叉菜胶诱发大鼠足肿胀模型和大鼠背部气囊模型、巴豆油混合致炎剂诱发小鼠耳肿胀模型以及鲁米诺化学发光法测定多形核白细胞(PMN)的发光强度。大鼠气囊炎性渗出液中前列腺素E2(prostaglandin E2,PGE2)、白细胞介素-6(interleukinI,L-6)和大鼠血清皮质醇用放射免疫法测定,一氧化氮(nitric oxide,NO)用硝酸还原酶法测定。结果:柴郁汤对大鼠足肿胀有显著抑制作用,能明显减少气囊炎性渗液中PGE2I、L-6、NO,对气囊模型大鼠血清皮质醇含量无明显影响,柴郁汤药物血清和姜黄素能明显抑制激活的PMN化学发光。结论:柴郁汤有明显的抗炎作用,其抗炎作用机制部分在于抑制PGE2、NOI、L-6的产生,抑制PMN产生氧自由基,但与影响下丘脑-垂体-肾上腺皮质轴无关。
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| 关 键 词： | 柴郁汤 抗炎 前列腺素E2 白介素-6 一氧化氮 |
Mechanism of Chaiyu Decoction on anti-inflammation effects |
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| Zhu Aijiang,Fang Buwu,Wu Xianzhong,Tian Zaishan,Zhang Yongjin,Guo Shiduo,Li Donghua.Mechanism of Chaiyu Decoction on anti-inflammation effects[J].Pharmacology and Clinics of Chinese Materia Medica,2011(3):98-101. |
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| Authors: | Zhu Aijiang Fang Buwu Wu Xianzhong Tian Zaishan Zhang Yongjin Guo Shiduo Li Donghua |
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| Affiliation: | Zhu Aijiang1,Fang Buwu2,Wu Xianzhong3,Tian Zaishan3,Zhang Yongjin2,Guo Shiduo3,Li Donghua3(1 Tianjin Third Central Hospital,Tianjin 300170,2Tianjin Medical University,Tianjin 300070,3 Institute of Acute Abdomen of Integrated Traditional and Western Medicine of Tianjin,Tianjin 300100) |
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| Abstract: | Objective:To inquire into the mechanism of Chaiyu decoction effects on inflammation.Methods:Rat foot-swelling model and rat back air-cyst model induced with carrageenin and mouse ear-swelling model induced with croton oil mixed inflammatory agent were used.Polymorphonuclear neutrophil leukocyte(neutrophil,PMN) luminous intensity was determined through luminal chemiluminescence.Prostaglandin E2(PGE2) and interleukin-6(IL-6) in rat air-cyst inflammatory effusion and rat serum cortisol were determined with rad... |
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