针刺调控α7nAchR激活胆碱能抗炎通路的研究现状

胆碱能抗炎通路是一条神经免疫通路,主要依靠乙酰胆碱与巨噬细胞及其他细胞表面上的α7nAchR相结合抑制促炎因子的合成与释放,从而防止组织损伤。α7nAchR是胆碱能递质的主要受体,在胆碱能抗炎通路中起关键作用。针刺治疗有明确的抗炎作用,其作用机制可能与调控α7nAchR激活胆碱能抗炎通路有关。近年来虽然国内外学者对针刺抗炎机制进行了大量研究,然而针刺抗炎的作用机制目前仍不明确。该文从胆碱能抗炎通路概述、α7nAchR结构及功能、α7nAchR的分布、α7nAchR在胆碱能抗炎通路的作用、针刺调控α7nAchR激活胆碱能抗炎通路的机制等方面对针刺调控α7nAchR激活胆碱能抗炎通路进行分析总结,为今后探究针刺抗炎作用机制提供借鉴思路和科学依据。

Current Research on Acupuncture Regulation of α7nAChR Activation of Cholinergic Anti-inflammatory Pathway

The cholinergic anti-inflammatory pathway is a neuroimmune pathway.It prevents tissue damage mainly through acetylcholine binding to a7 nAChR on the surface of macrophages and other cells to inhibit the synthesis and release of pro-inflammatory factors.The a7 nAChR is the main receptor for cholinergic transmitters and plays a key role in the cholinergic anti-inflammatory pathway.Acupuncture has a definite anti-inflammatory effect.Its mechanism of action may be related to regulating a7 nAChR activation of cholinergic anti-inflammatory pathway.Although scholars at home and abroad have made a lot of studies on the anti-inflammatory mechanism of acupuncture in recent years,the mechanism of anti-inflammatory action of acupuncture is now still unclear.This article analyzes and summarizes acupuncture regulation of a7 nAChR activation of cholinergic anti-inflammatory pathway from an overview of cholinergic anti-inflammatory pathway,a7 nAChR structure and function,a7 nAChR distribution,the role of a7 nAChR in cholinergic anti-inflammatory pathway and the mechanism of acupuncture regulation of a7 nAChR activation of cholinergic anti-inflammatory pathway so as to provide reference ideas and scientific basis for future exploration of the mechanism of anti-inflammatory action of acupuncture.