针灸联合龙胆泻肝汤对子宫脱垂患者血清TGF-β1、MMP-2、TIMP-2表达的影响

目的观察针灸联合龙胆泻肝汤治疗子宫脱垂的临床疗效及对患者血清TGF-β1、MMP-2、TIMP-2表达水平的影响。方法 296例子宫脱垂患者随机分为研究组和对照组,每组148例。对照组采用龙胆泻肝汤治疗,研究组在对照组的基础上采用针灸治疗。观察两组治疗前后的盆底功能障碍评分变化、盆底肌力评分变化及血清转化生长因子-β1 (TGF-β1)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶抑制剂-2(TIMP-2)表达水平变化,并比较两组临床疗效。结果研究组愈显率优于对照组(P<0.05)。两组治疗后盆底功能障碍评分较同组治疗前降低,研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗后盆底肌力评分高于对照组(P<0.05)。两组治疗后血清TGF-β1、MMP-2、TIMP-2表达水平与同组治疗前比较,差异有统计学意义(P<0.05);研究组治疗后血清TGF-β1、TIMP-2表达水平高于对照组(P><0.05),MMP-2表达水平低于对照组(P<0.05)。结论针灸联合龙胆泻肝汤能显著提高PDF患者的临床疗效,缓解患者的临床症状,改善患者血清TGF-β1、MMP-2、TIMP-2的表达水平。

Effect of Acupuncture-moxibustion plus Long Dan Xie Gan Decoction on TGF-1, MMP-2 and TIMP-2 Expressions in Hysteroptosis Patients

Objective To investigate clinical efficacy of acupuncture-moxibustion plus Long Dan Xie Gan decoction for hysteroptosis and its effect on TGF-β1,MMP-2 and TIMP-2 expression levels in the patients.Method Two hundred and ninety-six hysteroptosis patients were randomized to research and control groups,with 148 cases in each group.The control group received Long Dan Xie Gan decoction and the research group,acupuncture-moxibustion in addition.The pelvic floor dysfunction score and the pelvic floor muscle strength score were recorded and transforming growth factor-β1(TGF-β1),matrix metalloproteinase-2(MMP-2) and tissue inhibitor of metalloproteinase-2(TIMP-2) expression levels were determined in the two groups before and after treatment.The clinical therapeutic effects were compared between the two groups.Result The cure and marked efficacy rate was higher in the research group than in the control group(P<0.05).After treatment,the pelvic floor dysfunction score decreased in the two groups compared with before and was lower in the research group than in the control group with a statistically significant difference(P<0.05).The pelvic floor muscle strength score was higher in the research group than in the control group after treatment(P<0.05).There were statistically significant pre-/post-treatment differences in TGF-β1,MMP-2 and TIMP-2 expression levels in the two groups(P<0.05).After treatment,TGF-β1 and MMP-2 expression levels were higher(P<0.05) and TIMP-2 expression levels were lower(P<0.05) in the research group than in the control group.Conclusion Acupuncture-moxibustion plus Long Dan Xie Gan decoction can markedly heighten the clinical therapeutic effect,relive the clinical symptoms and improve TGF-β1,MMP-2 and TIMP-2 expression levels in PDF patients.