| 基于药动学的甘草配伍减毒机制研究进展 |
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| 引用本文： | 李志华,颜苗,张毕奎,李焕德,方平飞.基于药动学的甘草配伍减毒机制研究进展[J].中草药,2015,46(23):3611-3616. |
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| 作者姓名： | 李志华 颜苗 张毕奎 李焕德 方平飞 |
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| 作者单位： | 中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学药学院, 湖南 长沙 410013;中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学临床药学研究所, 湖南 长沙 410011;中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学临床药学研究所, 湖南 长沙 410011;中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学临床药学研究所, 湖南 长沙 410011;中南大学湘雅二医院药学部, 湖南 长沙 410011;中南大学临床药学研究所, 湖南 长沙 410011 |
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| 基金项目： | 国家自然科学基金资助项目(81202985,81473411) |
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| 摘 要： | 甘草在中药方剂中使用相当普遍,通常作为佐药和使药,起着制约主药毒性、调和诸药的作用;甘草作为"和诸药,解百毒"药物,常与有毒中药配伍使用,但其中的配伍原理还未明确。研究甘草对有毒中药主要成分体内过程的影响,能够更加深入地认识方剂配伍使用的原理和规律,以及该过程与其配伍减毒的关系。主要总结近年来关于甘草配伍对有毒中药体内过程的影响及其药动学减毒机制的研究进展。
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| 关 键 词： | 甘草 药动学 减毒机制 药物代谢酶 外排转运体 |
| 收稿时间： | 2015/3/20 0:00:00 |
Advances in study on compatibility of licorice and its mechanism of detoxification based on pharmacokinetics |
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| LI Zhi-hu,YAN Miao,ZHANG Bi-kui,LI Huan-de and FANG Ping-fei.Advances in study on compatibility of licorice and its mechanism of detoxification based on pharmacokinetics[J].Chinese Traditional and Herbal Drugs,2015,46(23):3611-3616. |
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| Authors: | LI Zhi-hu YAN Miao ZHANG Bi-kui LI Huan-de and FANG Ping-fei |
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| Affiliation: | Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China;School of Pharmaceutical Science, Central South University, Changsha 410013, China;Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China;Institute of Clinical Pharmacy, Central South University, Changsha 410011, China;Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China;Institute of Clinical Pharmacy, Central South University, Changsha 410011, China;Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China;Institute of Clinical Pharmacy, Central South University, Changsha 410011, China;Department of Pharmacy, the Second Xiangya Hospital, Central South University, Changsha 410011, China;Institute of Clinical Pharmacy, Central South University, Changsha 410011, China |
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| Abstract: | Licorice is one of Chinese materia medica (CMM) widely used in Chinese medicinal formulae as assistant and guiding medicines, it plays a role in restricting the main drug's toxicity and moderating the property of herbs. Licorice is regarded as a herb that can moderate the property of each herb and remove the hundreds of toxicants. Based on the above characteristics, toxic CMM is always used with licorice. However, the mechanism of the compatibility of licorice is not very clear. It is a good way for us to understand the principle and law of the compatibility of licorice, and to know the relationship between the process and compatibility detoxifying mechanism of licorice through studying on how the licorice has an effect on intracorporal process of the main components in the toxic CMM. The paper mainly summarizes the study on the pharmacokinetics of toxic CMM by compatibility of licorice and its mechanism of pharmacokinetic detoxification. |
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| Keywords: | licorice pharmacokinetics mechanism of detoxification drug metabolic enzymes efflux transporters |
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