黄精的研究进展及其质量标志物的预测分析

黄精是中国传统的中药材,主要分布于北温带和北亚热带,广泛分布于我国南方广大地区。随着对黄精药理、药物化学及临床研究的逐步深入,黄精属植物的活性部位及有效成分的研究也为新药研发所重视。着重对黄精资源、化学成分、主要药理活性进行总结。黄精的多种化学成分,包括多糖、甾体皂苷、三萜、生物碱、木脂素、黄酮、植物甾醇等,其中多糖和甾体皂苷类成分在黄精中量较大,为其主要药效成分。在此基础上,比较黄精、滇黄精和多花黄精中的主要化学成分的差异性,为确定黄精质量标志物提供依据;并研究黄精多糖、甾体皂苷和异黄酮类化合物对主要药效的贡献。建议开展黄精质量标准和质量标志物研究,选择质优的黄精进行黄精多糖、甾体皂苷和异黄酮类化合物的定性、定量分析,为定量标准的制定提供科学数据。

Research progress in Polygonati Rhizoma and predictive analysis on Q-marker

Polygonati Rhizoma (PR) is a traditional Chinese herbal medicine, mainly distributed in the North Temperate Zone and North Subtropical Zone, widely spread over the south China. As the progress of PR in pharmacology, medicinal chemistry, and clinical research, the study of Polygonatum''s active site and effective components are attached much attention in new drug research and development. In this paper, the resources, chemical composition, pharmacological activity, and clinical application of PR are summarized. Literature research suggests a variety of chemical composition in PR, including polysaccharide, steroidal saponins, terpene, alkaloid, wooden fat element, flavonoids, and phytosterols, in which polysaccharides and steroidal saponins class are the main efficacy components. On the base, the difference of the main chemical composition are compared in P. sibiricum, P. kingianum and P. cyrtonema, to provide experiment basis for Q-maker determining; And the contribution of polygonatum polysaccharide, steroidal saponins and isoflavone compounds to the main therapeutic effects were been studied. It is suggested to carry out the quality standard and Q-marker research in PR-the qualitative and quantitative analysis of polysaccharide, steroidal saponins and isoflavone compounds in the high quality PR and compare the quantitative limit of different batches, to provide scientific data for quality standard setting.