| 微生物发酵技术在中药苷类生物转化中的应用进展 |
| |
| 引用本文： | 马宗敏,段绪红,秦梦,黄璐琦,裴林.微生物发酵技术在中药苷类生物转化中的应用进展[J].世界科学技术-中医药现代化,2017,19(5):858-864. |
| |
| 作者姓名： | 马宗敏 段绪红 秦梦 黄璐琦 裴林 |
| |
| 作者单位： | 1. 河北省中医药科学院浊毒证重点实验室 石家庄 050031,1. 河北省中医药科学院浊毒证重点实验室 石家庄 050031,1. 河北省中医药科学院浊毒证重点实验室 石家庄 050031,2. 中国中医科学院中药研究所 北京 100700,1. 河北省中医药科学院浊毒证重点实验室 石家庄 050031 |
| |
| 基金项目： | 中央本级重大增减支项目（2060302）：名贵中药资源可持续利用能力建设，负责人：黄璐琦、裴林；河北省中医药管理局科研计划项目（2015087）：黄芩内生菌的分离及其对黄芩生物转化研究，负责人：马宗敏。 |
| |
| 摘 要： | 苷类是诸多中药的主要活性成分之一。近年来，因其抗炎、抗病毒、增强免疫、抗癌等药理活性的发现，苷类中药成分越来越受到研究者的重视。绝大多数苷类经肠道微生物发酵转化为苷元或低糖苷等成分发挥药效，为了提高苷类成分的生物利用度，在体外将苷类物质转化为相应活性成分，就成为十分有意义的研究课题。微生物发酵技术因其反应特异性强、副产物少、反应条件温和、清洁环保等优点在中药转化领域具有独特优势，利用微生物对苷类中药进行转化的研究大量涌现。本文对近年来微生物发酵转化中药苷类活性成分的研究进展进行展望。
|
| 关 键 词： | 苷 苷元 中药 微生物转化 |
| 收稿时间： | 2017/3/10 0:00:00 |
| 修稿时间： | 2017/4/28 0:00:00 |
Microbial Transformation of Glycosides in Chinese Herbal Medicine |
| |
| Ma Zongmin,Duan Xuhong,Qin Meng,Huang Luqi and Pei Lin.Microbial Transformation of Glycosides in Chinese Herbal Medicine[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2017,19(5):858-864. |
| |
| Authors: | Ma Zongmin Duan Xuhong Qin Meng Huang Luqi and Pei Lin |
| |
| Affiliation: | 1. Key Laboratory of Zhuo-Du Syndrome, Hebei Provincial Academy of Traditional Chinese Medicine, Shijiazhuang 050031, China,1. Key Laboratory of Zhuo-Du Syndrome, Hebei Provincial Academy of Traditional Chinese Medicine, Shijiazhuang 050031, China,1. Key Laboratory of Zhuo-Du Syndrome, Hebei Provincial Academy of Traditional Chinese Medicine, Shijiazhuang 050031, China,2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China and 1. Key Laboratory of Zhuo-Du Syndrome, Hebei Provincial Academy of Traditional Chinese Medicine, Shijiazhuang 050031, China |
| |
| Abstract: | Glycosides are the active ingredients (AIs) of many Chinese herbs and have become hot spots along with the findings of their new functions, such as anti-inflammatory, antivirus, enhanced immunity and anti-cancer. It has been found that glycosides exert their effects by converting to aglycons or other AIs in vivo. Therefore, the transformation of glycosides to the corresponding AIs in vitro becomes very important to enhance their bioavailabilities. The microbial transformation has an unparalleled advantage in the transformation of Chinese herbs in vitro for its reaction specificity, less by- products, mild reaction conditions and environmental protection. This paper summarized and prospected researches of glycosides?? microbial transformation. |
| |
| Keywords: | |
|
| 点击此处可从《世界科学技术-中医药现代化》浏览原始摘要信息 |
|
点击此处可从《世界科学技术-中医药现代化》下载全文 |
|
