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Huangqi Decoction,a compound Chinese herbal medicine,inhibits the proliferation and activation of hepatic stellate cells by regulating the long noncoding RNA-C18orf26-1/microRNA-663a/transforming growth factor-β axis
Affiliation:1. Traditional Chinese Medicine Epigenomics Research Center, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Department of Rheumatology and Immunology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing 211299, Jiangsu Province, China;3. Department of Rheumatology and Immunology, Yangzhou University Medical College, Yangzhou 225000, Jiangsu Province, China;4. Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan;5. Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;1. State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology (Ministry of Education), School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China;2. Department of Clinical Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China;3. Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Wenzhou 325000, Zhejiang Province, China;4. Yantai Fuheng Biological Technology Co., Ltd., Yantai 264006, Shandong Province, China;1. Department of General Practice, Changhai Hospital, Naval Medical University, Shanghai 200433, China;2. Department of General Practice, Changhai Hongkou Hospital, Shanghai 200081, China;3. Department of Special Clinic, Changhai Hospital, Naval Medical University, Shanghai 200433, China;4. Shanghai Institute of Biochemical and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;5. Department of Nursing, Shidong Hospital, University of Shanghai for Science and Technology, Shanghai 200438, China;6. Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China;1. Department of Chinese Medicine, Taoyuan General Hospital, Taoyuan City 330, Taiwan, China;2. Department of Nephrology, Taoyuan General Hospital, Taoyuan City 330, Taiwan, China;3. Department of Infectious Disease, Taoyuan General Hospital, Taoyuan City 330, Taiwan, China;4. School of Public Health, Taipei Medical University, Taipei City 110, Taiwan, China;5. Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan City 320, Taiwan, China;6. School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung City 404, Taiwan, China;7. School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan City 333, Taiwan, China;1. School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan, China;2. Nursing Department, En Chu Kong Hospital, New Taipei 23702, Taiwan, China;3. Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan, China;4. Cochrane Taiwan, Taipei Medical University, Taipei 11031, Taiwan, China;5. School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, China
Abstract:
Keywords:Long noncoding RNA-C18orf26-1  MicroRNA-663a  Transforming growth factor-β  Hepatic stellate cells  Huangqi Decoction
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