| 大孔吸附树脂纯化丹参总酚酸的工艺研究 |
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| 引用本文： | 张霄翔,邵胜男,周慧慧,姚日生.大孔吸附树脂纯化丹参总酚酸的工艺研究[J].中成药,2007,29(9):1288-1291. |
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| 作者姓名： | 张霄翔 邵胜男 周慧慧 姚日生 |
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| 作者单位： | 1. 合肥工业大学制药工程系;合肥工业大学生物化工教育部重点实验室,安徽,合肥,230009
2. 合肥工业大学制药工程系 |
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| 摘 要： | 目的:研究D101大孔树脂分离纯化丹参总酚酸的工艺条件及参数。方法:采用正交实验法,以大孔树脂柱上总酚酸的保留率作为考察指标,对影响总酚酸纯化效果的主要因素进行考察。结果:水洗液体积及上样液中总酚酸质量对树脂柱上总酚酸的保留率具有显著影响。采用大孔树脂分离纯化丹参粗提物中总酚酸,树脂柱上总酚酸的保留率可达87.52%,纯化后样品中总酚酸含量达到77.74%,总酚酸含量比粗提物中总酚酸含量提高了3.6倍。结论:采用大孔树脂分离纯化丹参总酚酸的方法是可行的,可应用于丹参总酚酸的工业化生产。
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| 关 键 词： | 丹参 总酚酸 大孔树脂 正交实验 |
| 文章编号： | 1001-1528（2007）09-1288-04 |
| 修稿时间： | 2006-11-09 |
Purification process of total salvianolic acid of Radix Salvia Miltiorrhizae with macroreticular resin |
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| ZHANG Xiao-xiang,SHAO Sheng-nan,ZHOU Hui-hui,YAO Ri-sheng.Purification process of total salvianolic acid of Radix Salvia Miltiorrhizae with macroreticular resin[J].Chinese Traditional Patent Medicine,2007,29(9):1288-1291. |
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| Authors: | ZHANG Xiao-xiang SHAO Sheng-nan ZHOU Hui-hui YAO Ri-sheng |
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| Affiliation: | 1. Department of Pharmaceutical Engineering, Hefei University of Technology; 2. Key Laboratory of Bio-process, Ministry of Education, Hefei University of Technology; Hefei 230009, Anhui, China |
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| Abstract: | AIM: To study the technological parameters of the purification process of total salvianolic acid(TSA) of Radix Salvia Miltiorrhizae(RSM) with D101 macroreticular resin. METHODS: Based on orthogonal experiment,the reservation rate of TSA in macroreticular resin columniation was took as index to investigate the chief influential factors in the purification of TSA. RESULTS: The volume of distilled water and the content of TSA in RSU solution had significant effect on the reservation rate of TSA in macroreticular resin columniation. With the help of macroreticular resin,the reservation rate of TSA could reach 87.52%.Its purity was 77.74%,comparing with crude extract,increased by 3.6 times. CONCLUSION: The method of purifing TSA of RSM with D101 macroreticular resin is feasible,it could be applied to industrialized production of TSA of RSM. |
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| Keywords: | Radix Salvia Miltiorrhizae total salvianolic acid macroreticular resin orthogonal experiment |
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