| 肉桂酸透皮吸收的实验研究 |
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| 引用本文： | 朱卫丰,张亚红,刘红宁,徐莲英,杨武亮,谢平.肉桂酸透皮吸收的实验研究[J].中成药,2003,25(6):443-445. |
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| 作者姓名： | 朱卫丰 张亚红 刘红宁 徐莲英 杨武亮 谢平 |
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| 作者单位： | 1. 江西中医学院,江西,南昌,330006
2. 上海中医药大学,上海,200032 |
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| 摘 要： | 目的：研究肉桂酸透皮吸收及一些常用助渗剂，pH值对其透皮特性的影响。方法：采用K—C扩散池进行体外扩散实验，选择离体小鼠皮肤为渗透屏障，从接收池取样，用HPLC检测法测定样品中肉桂酸的含量。结果：肉桂酸可以透过离体小鼠皮肤；其渗透系数随其浓度增加而增加；20％乙醇、30％乙醇、3％氮酮对肉桂酸有显著促渗透作用。结论：本研究将为含肉桂酸中药经皮给药提供实验依据。
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| 关 键 词： | 肉桂酸 透皮吸收 氮酮 小鼠 |
| 文章编号： | 1001-1528(2003)06-0443-02 |
| 修稿时间： | 2002年10月6日 |
Experimental study on percutaneous absorption of cinnamic acid |
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| ZHU Wei-feng ,ZHANG Ya-hong ,LIU Hong-ning ,XU Lian-ying ,YANG Wu-liang ,XIE Ping.Experimental study on percutaneous absorption of cinnamic acid[J].Chinese Traditional Patent Medicine,2003,25(6):443-445. |
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| Authors: | ZHU Wei-feng ZHANG Ya-hong LIU Hong-ning XU Lian-ying YANG Wu-liang XIE Ping |
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| Affiliation: | ZHU Wei-feng 1,ZHANG Ya-hong 1,LIU Hong-ning 1,XU Lian-ying 2,YANG Wu-liang 1,XIE Ping 2 |
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| Abstract: | Objective: To study percutaneous absorption of cinnamic acid and the effect of some common enhancers and pH value on it. Methods: Drug permeation tests were performed in K-C two-compartment diffusion cell through excised mice skin. Samples were collected from the receiver compartment, cinnamic acid concentration in samples was determined by HPLC. Results: Cinnamic acid could penetrate through excised mice skin. The permeability coefficient of cinnamic acid rose as its concentration increased. Cinnamic acid consisted of 20% ethanol, 30% ethanol and 3% Azone had high penetrating power. Conclusion: The research will provide experimental data for skin administration of Chinese medicine holding cinnamic acid. |
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| Keywords: | cinnamic acid percutaneous absorption Azone ncouse |
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