独活寄生汤联合塞来昔布及关节腔注射玻璃酸钠治疗肝肾不足型膝骨关节炎患者效果观察

目的:探讨分析独活寄生汤联合塞来昔布及关节腔注射玻璃酸钠治疗肝肾不足型膝骨关节炎患者的效果。方法:选取114例肝肾不足型膝骨关节炎患者随机分为观察组和对照组,观察组给予独活寄生汤联合塞来昔布及关节腔注射玻璃酸钠治疗,对照组仅给予塞来昔布及关节腔注射玻璃酸钠治疗,比较两组临床疗效,治疗前后疼痛视觉模拟评分法(Visual Analogue Scale,VAS)评分、奎森功能演算指数评分(Lequesne评分)、炎性因子水平及中医症状评分。结果:观察组临床疗效总有效率较对照组显著性提高(P<0.05),治疗前两组VAS、Lequesne评分无显著性差异(P>0.05),治疗后两组VAS、Lequesne评分均显著性降低,且治疗后观察组VAS、Lequesne评分下降更显著(P<0.05);治疗前两组白细胞介素-1β(Interleukin-1β,IL-1β)、肿瘤坏死因子α(Tumor Necrosis Factor,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)指标水平无显著性差异(P>0.05),治疗后两组IL-1β、TNF-α、IL-6指标水平均显著性降低,且治疗后观察组IL-1β、TNF-α、IL-6指标水平下降更显著(P<0.05);治疗前两组膝关节疼痛、腰膝沉重症状评分无显著性差异(P>0.05),治疗后两组膝关节疼痛、腰膝沉重症状评分均显著降低,且治疗后观察组膝关节疼痛、腰膝沉重评分下降更显著(P<0.05)。结论:独活寄生汤联合塞来昔布及关节腔注射玻璃酸钠治疗肝肾不足型膝骨关节炎疗效显著,能缓解患者疼痛,恢复关节功能,降低炎症因子水平,促进患者生活质量的提高,值得推广。

Efficacy of the Duhuo Jisheng decoction plus celecoxib and sodium hyaluronate intraarticular injection on the Ganshen Buzu type knee osteoarthritis

Objective:To explore the effects of the Duhuo Jisheng decoction(独活寄生汤)plus celecoxib and sodium hyaluronate intraarticular injection on the Ganshen Buzu type(肝肾不足型)knee osteoarthritis.Methods:114 cases were randomly divided into the observation group and the control group.The observation group was treated with the Duhuo Jisheng decoction plus celecoxib and sodium hyaluronate intraarticular injection,and the control group was given celecoxib with sodium hyaluronate intraarticular injection.Results:The total efficiency in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in VAS scores and Lequesne scores between the groups before treatment(P>0.05),and the VAS scores and Lequesne scores in the groups were significant decreased after treatment,and the decrement in the observation group was more significant(P<0.05).Before treatment,IL-1β,TNF-αand IL-6 levels in the groups showed no statistically significant difference(P>0.05);after treatment,the levels of IL-1β,TNF-αand IL-6 in the groups were all significantly reduced,and the decrement in the observation group was more significant(P<0.05).After treatment,knee pain scores,and waist and knee heaviness symptoms scores in the groups were significantly decreased,and the decrement in the observation group was more significant(P<0.05).Conclusion:The Duhuo Jisheng decoction plus celecoxib and sodium hyaluronate intraarticular injection are effective in treating the Ganshen Buzu type knee osteoarthritis,which can relieve pain,restore joint function,reduce the level of inflammatory factors,improve the life quality of patients,and is worth promoting.